Postdoc: Time-Resolved, Room-Temp Crystallography

Instruct-ERIC; Schweiz; On-site; CHF 90,000 - 110,000; Full time

Job summary

Paul Scherrer Institute in Switzerland is seeking a Postdoctoral Fellow in Time-resolved and Room-temperature Crystallography to join the Macromolecular Crystallography group.

You will work at the PXI-VESPA endstation and other SLS MX beamlines, performing time-resolved experiments, developing SSX workflows, studying radiation damage, and publishing results with international collaborators.

Qualifications

• PhD in structural biology, biophysics, biochemistry, chemistry, physics or related field.
• Hands-on experience in macromolecular crystallography from data collection to refinement.
• Experience in serial and/or time-resolved crystallography at synchrotrons or XFELs.
• Strong English written and spoken.
• Desirable: protein production and (micro)crystallisation, reaction initiation or enzyme kinetics.
• Desirable: programming skills (Python) and CrystFEL / XDS.

Responsibilities

• Work at PXI-VESPA and other SLS MX beamlines with beamline scientists.
• Implement and run time-resolved experiments with injector and pump–probe.
• Apply methods to dynamic structural enzymology to capture intermediates.
• Establish SSX workflows on cryo-compatible fixed-target chips.
• Characterise X-ray heating and radiation damage and derive data-collection protocols.
• Publish results and present at international conferences and support users.

Skills

Macromolecular crystallography

Time-resolved crystallography

Serial crystallography

Python programming

XDS/CrystFEL experience

English proficiency

Education

PhD in structural biology/biophysics/biochemistry/chemistry/physics

Tools

CrystFEL

XDS

JUNGFRAU detector

IMISX/MISP-chip

Job description

Paul Scherrer Institute in Switzerland is seeking a Postdoctoral Fellow in Time-resolved and Room-temperature Crystallography to join the Macromolecular Crystallography group.

You will work at the PXI-VESPA endstation and other SLS MX beamlines, performing time-resolved experiments, developing SSX workflows, studying radiation damage, and publishing results with international collaborators.