Postdoc: Time-Resolved Room-Temp Crystallography

EPFL CED Centre d'Employabilité et de Développement / Employability and Development Center; Schweiz; Remote; CHF 90,000 - 110,000; Full time

Job summary

The Paul Scherrer Institute invites applications for a Postdoctoral Fellow in Time-resolved and Room-temperature Crystallography at the MX beamlines. You will work at the new PXI-VESPA endstation, collaborating with beamline scientists and software experts to push time-resolved crystallography at room temperature.

You will implement experiments, study reaction dynamics, establish SSX workflows, and disseminate findings through publications and conferences, while mentoring external users.

Qualifications

• PhD in structural biology, biophysics, biochemistry, chemistry, physics or related field.
• Hands-on MX crystallography experience from data collection to refinement.
• Experience in serial/time-resolved crystallography at synchrotrons or XFELs.
• Interdisciplinary teamwork in a large research facility.
• Excellent written and spoken English.

Responsibilities

• Implement and run time-resolved experiments with miniature injectors and pump–probe schemes.
• Apply methods to dynamic structural enzymology to capture intermediates.
• Establish SSX workflows on cryo-compatible chips for dynamic studies.
• Characterise X-ray heating and radiation damage at room temperature.
• Publish results and support external users and collaborators.

Skills

Time-resolved crystallography

Serial crystallography

X-ray data processing

Python programming

English proficiency

Education

PhD in structural biology

Tools

CrystFEL

XDS

Job description

The Paul Scherrer Institute invites applications for a Postdoctoral Fellow in Time-resolved and Room-temperature Crystallography at the MX beamlines. You will work at the new PXI-VESPA endstation, collaborating with beamline scientists and software experts to push time-resolved crystallography at room temperature.

You will implement experiments, study reaction dynamics, establish SSX workflows, and disseminate findings through publications and conferences, while mentoring external users.