PhD Student: Mechanobiology & High-Throughput Proteins

Master in Integrated Building Systems ETH Zürich; Basel; Vor Ort; CHF 80.000 - 100.000; Vollzeit

Zusammenfassung

ETH Zurich's Nash Lab invites applications for a Doctoral Student position at the interface of protein engineering, mechanobiology, and machine learning. Work spans high-throughput experimental design, sequencing analysis, and computational modeling, with collaboration across Basel and ETH Zurich groups.

You will develop assays, analyze large datasets, and contribute to publications while enrolling in the D-BSSE Doctoral program in Basel.

Qualifikationen

• Master's degree in a relevant field (bioengineering, chemical engineering, biochemistry, molecular biology, biophysics)
• Strong quantitative background and interest in protein engineering, mechanobiology, high-throughput methods
• Hands-on experience with molecular biology and protein expression; yeast display or AFM experience is a plus

Aufgaben

• Establish and validate a high-throughput assay for protein-protein interactions under mechanical stress
• Cross-validate assay results against AFM measurements
• Design and construct DNA variant libraries and display on yeast
• Apply next-generation sequencing to quantify phenotypes
• Develop computational pipelines to convert sequencing data into fitness values
• Collaborate with computational biology to benchmark ML models
• Prepare data and manuscripts for publication and present results
• Enroll in and complete the D-BSSE Doctoral program in Basel
• Contribute to undergraduate teaching and chemistry practicals

Kenntnisse

Quantitative background

Protein engineering interest

Independent experimental work

Python / ML familiarity

Team collaboration

Ausbildung

Master's degree in bioengineering / related field

Tools

Yeast display

AFM

DNA sequencing

Jobbeschreibung

ETH Zurich's Nash Lab invites applications for a Doctoral Student position at the interface of protein engineering, mechanobiology, and machine learning. Work spans high-throughput experimental design, sequencing analysis, and computational modeling, with collaboration across Basel and ETH Zurich groups.

You will develop assays, analyze large datasets, and contribute to publications while enrolling in the D-BSSE Doctoral program in Basel.