PhD in High-Throughput Protein Interactions

Karlstad University; Zürich; Vor Ort; CHF 60.000 - 72.000; Vollzeit

Benefits dieser Stelle

Funding to attend conferences

Enrollment in Doctoral program

Collaborative environment

Zusammenfassung

ETH Zürich invites applications for a Doctoral Student position in high-throughput analysis of protein-protein interactions. The Nash Lab collaborates across ETH Zürich Basel and D-BSSE to develop experimental and computational approaches at the interface of protein engineering, biophysics, and machine learning.

Responsibilities include establishing high-throughput assays, sequencing-based phenotype quantification, and data-driven modeling, with opportunities for teaching and conference funding

Qualifikationen

• Master's degree in a bioengineering, chemistry, biophysics, or related field.
• Strong quantitative background and interest in protein engineering and mechanobiology.
• Hands-on molecular biology experience; yeast display or directed evolution advantageous.
• Willingness to learn computational analysis of large sequencing datasets (Python).

Aufgaben

• Establish and validate a high-throughput assay for measuring mechanical stability of protein-protein interactions.
• Cross-validate assay results against AFM measurements.
• Design and construct DNA variant libraries and display them on yeast.
• Apply next-generation sequencing to quantify phenotypes.
• Develop computational pipelines to convert sequencing data into fitness values.
• Collaborate with a computational biology group to develop ML models.
• Prepare data and manuscripts for publication and present results at labs and conferences.
• Enroll in and complete the D-BSSE Doctoral program in Basel.
• Contribute to undergraduate teaching and chemistry practicals.

Kenntnisse

Fluent English

Python

Ausbildung

Master's degree in bioengineering or related field

Tools

AFM

Sequencing data analysis

Jobbeschreibung

ETH Zürich invites applications for a Doctoral Student position in high-throughput analysis of protein-protein interactions. The Nash Lab collaborates across ETH Zürich Basel and D-BSSE to develop experimental and computational approaches at the interface of protein engineering, biophysics, and machine learning.

Responsibilities include establishing high-throughput assays, sequencing-based phenotype quantification, and data-driven modeling, with opportunities for teaching and conference funding