PhD Student — High-Throughput Protein Interactions & ML

Eidgenössische Technische Hochschule Zürich; Basel; Hybrid; CHF 58.000 - 75.000; Vollzeit

Benefits dieser Stelle

Doctoral supervision

Enrollment in Doctoral program

Conference funding

Interdisciplinary lab access

Competitive Swiss salary

Zusammenfassung

ETH Zurich's Nash Lab is offering a Doctoral Student position focused on high-throughput analysis of protein-protein interactions. You will work at the interface of protein engineering, mechanobiology, and machine learning, collaborating with the Beerenwinkel group at D-BSSE.

The role provides hands-on training across experimental design, sequencing, and predictive modeling. You will contribute to foundational research with relevance to blood clotting systems, participate in data and manuscript

Qualifikationen

• Master's degree in a bioscience/engineering field with strong quantitative skills.
• Interest in protein engineering, mechanobiology, or high-throughput methods.
• Hands-on experience with molecular biology and protein expression is preferred but not required.
• Willingness to learn computational analysis of large sequencing datasets (Python or equivalent).

Aufgaben

• Establish and validate a high-throughput assay for protein-protein interactions.
• Cross-validate assay results with AFM measurements.
• Design and construct DNA variant libraries; display them on yeast.
• Apply next-generation sequencing to quantify phenotypes.
• Develop pipelines to convert sequencing data into fitness values.
• Collaborate with a computational biology group on ML model development.
• Prepare data and manuscripts for publication and present results at meetings.
• Enroll in and complete the D-BSSE Doctoral program in Basel.
• Contribute to undergraduate teaching and chemistry practicals.

Kenntnisse

Quantitative background

Independent experimental work

Team collaboration

Teaching engagement

English proficiency

Ausbildung

Master's degree in bioengineering, biochemistry, biophysics, molecular biology or related field

Tools

Python or equivalent

Machine learning (basics)

Sequencing data analysis

Jobbeschreibung

ETH Zurich's Nash Lab is offering a Doctoral Student position focused on high-throughput analysis of protein-protein interactions. You will work at the interface of protein engineering, mechanobiology, and machine learning, collaborating with the Beerenwinkel group at D-BSSE.

The role provides hands-on training across experimental design, sequencing, and predictive modeling. You will contribute to foundational research with relevance to blood clotting systems, participate in data and manuscript