Doctoral position on molecular engineering of dynamic covalent hydrogels

Emerging Scholars Council; Zürich; Vor Ort; CHF 50.000 - 60.000; Vollzeit

Zusammenfassung

ETH Zurich's Macromolecular Engineering Laboratory invites applications for a full-time doctoral candidate starting on or after 01 October 2026. The project focuses on dynamic covalent hydrogels and the design-to-property framework to connect molecular features with macroscopic mechanics. The successful candidate will work in an interdisciplinary team, perform ITC, NMR, UV-Vis analyses, and contribute to computational modeling, with supervision by Prof.

Dr. Mark Tibbitt.

Qualifikationen

• MSc degree in chemical engineering, mechanical engineering, chemistry, materials science, physics, polymer science or related field.
• Experience with rheological characterization of soft materials and molecular binding analysis (ITC, NMR, UV-Vis).
• Fluent English (oral and written) required.

Aufgaben

• Synthesize and characterize a broad library of model dynamic covalent hydrogels (boronate ester, hydrazone, imine, disulfide) and network architectures.
• Quantify binding constants, thermodynamics, and reaction kinetics of reversible cross-links using ITC, NMR, and UV-Vis; relate to rheological properties.
• Develop theoretical and computational frameworks to capture entropy-driven network-scale effects and refine rubber elasticity models.
• Collaborate with an interdisciplinary team and contribute to teaching and lab supervision.

Kenntnisse

Rheological characterization

Calorimetry

NMR spectroscopy

UV-Vis spectroscopy

Polymer networks

Computational modeling

Organic synthesis

Ausbildung

MSc degree in chemical/ mechanical engineering, chemistry, materials science, physics, polymer science

Tools

ITC

NMR

UV-Vis

Jobbeschreibung

The Macromolecular Engineering Laboratory (Prof. Mark W. Tibbitt) within the Department of Mechanical and Process Engineering (D-MAVT) at ETH Zurich in Zurich, Switzerland engineers and applies advanced polymeric materials for a range of biomedical and industrial uses. The recent focus of the group (www.macro.ethz.ch/) includes the development of: (i) rational design of dynamic polymer networks; (ii) (bio)material processing; (iii) organ perfusion and regeneration; (iv) tools to study mechanobiology and cell-matrix interactions; and (v) engineered drug delivery systems. The lab is composed of a highly interdisciplinary and international team of motivated researchers. To expand on our understanding of how molecular-scale features govern the mechanics and flow of dynamic covalent hydrogels, we are recruiting a full-time (100%) doctoral candidate, with an intended starting date on or after 01. October 2026.

Project background

Dynamic covalent hydrogels (DCHs)-polymer networks cross-linked by reversible covalent bonds, such as boronate esters, hydrazones, imines, or disulfides- represent a compelling class of viscoelastic soft materials. Their tailorable mechanical properties, stimulus-responsiveness, and processability (injectable, printable) make them highly attractive for biomedical and industrial uses. However, the rational engineering of DCHs remains constrained by an incomplete understanding of how molecular-level features- bond thermodynamics, kinetics, network architecture- translate into macroscopic material properties such as the plateau modulus G0 and the relaxation time tR. Building a rigorous, quantitative framework linking molecular behavior to macroscale properties is the central aim of this project.

Job Description

This doctoral project has two main, interrelated thrusts. In the first, the student will synthesize and characterize a broad library of model DCHs spanning a range of dynamic covalent chemistries (boronate ester, hydrazone, imine, and disulfide bonds) and network architectures (ideal, real, and interpenetrating networks). The student will quantify the equilibrium binding constants, binding thermodynamics, and reaction kinetics of the reversible cross-links using isothermal titration calorimetry (ITC), NMR spectroscopy (including 2D EXSY), and UV-vis/fluorescence techniques, and relate these to the macroscale rheological properties measured by shear rheometry and nano-indentation. A key and largely unexplored question is how the macromolecular nature of the binding partners - as opposed to small-molecule analogues - influences binding behavior and network mechanics, which the student will investigate systematically. In the second thrust, the student will develop theoretical and computational frameworks, in close collaboration with Prof. Vlasios Mavrantzas (a collaborator in the lab), to capture entropy-driven network-scale effects and refine rubber elasticity models for dynamic networks. Complementary studies of non-linear flow behavior using shear rheometry and microfluidic flow cells will provide insight into DCH processability for injectable biomaterial design. The doctoral student will work in close collaboration with and be supported by an interdisciplinary team of doctoral students and postdocs working on related topics. In addition to research, the PhD candidate is expected to contribute to lab duties and will have the opportunity to contribute to teaching within the group, including student supervision, lecture support, and practical courses in the lab.

Profile

We are seeking a curious, motivated, and self-driven individual, who is comfortable working on interdisciplinary projects spanning macromolecular chemistry, soft matter physics, and physical chemistry. Academic excellence, a professional work attitude, and a proactive and self-driven work ethic are expected. Moreover, the candidate must be able to fluently communicate in English (oral and written) and be willing to work in a highly interactive, international team. Applicants must hold a MSc degree in chemical engineering, mechanical engineering, chemistry, materials science, physics, polymer science, or related fields. A working knowledge of organic synthesis and polymer chemistry is required. Practical experience in one or more of the following would be advantageous: rheological characterization of soft materials, calorimetric or spectroscopic analysis of molecular binding (ITC, NMR, UV-vis), design of polymer networks, or computational modeling of polymeric systems. The doctoral position is intended for 4 years, at 100% employment, and will be supervised by Prof. Dr. Mark Tibbitt. The position is funded by the Swiss National Science Foundation and is conditional upon admission to the Doctoral Program at ETH Zurich.

We offer

The position is hosted in the Department of Mechanical and Process Engineering (D-MAVT) of the ETH Zurich, in the Zentrum Campus in Zurich, Switzerland. D-MAVT (https://mavt.ethz.ch/) is an interdisciplinary department with focus areas in process/chemical, mechanical, and biomedical engineering as well as robotics and controls. ETH Zurich (https://ethz.ch/en/) is a global leader in science and engineering and consistently ranks among the top universities in the world. Zurich is an international city with broad access to outdoor activities, arts and culture, other European cities, as well as a rich and excellent scientific community.

We value diversity and sustainability

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish. Sustainability is a core value for us - we are consistently working towards a climate-neutral future.

Curious? So are we.

About ETH Zürich

ETH Zurich is one of the worlds leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.