DEL Platform Chemist: Next‑Gen Libraries & Hit Discovery

Monte Rosa Therapeutics, Inc.; Basel; Vor Ort; CHF 90.000 - 130.000; Vollzeit

Zusammenfassung

Monte Rosa Therapeutics, Inc. is seeking a highly motivated scientist to advance our DNA-encoded library (DEL) platform.

You will design next-generation DEL libraries, optimize encoding strategies, and refine selection methodologies to enable discovery of high-quality chemical starting points for challenging targets. Join a collaborative team interfacing Chemistry, Biology, Data Science, and Biophysics to accelerate drug discovery.

Qualifikationen

• PhD in a relevant chemistry field with strong DEL background.
• Proven expertise in DEL design, encoding and selection workflows.
• Experience translating DEL insights into actionable chemical matter.
• Publications or patents in DEL tech are a plus.

Aufgaben

• Contribute to design and evolution of next-gen DEL libraries.
• Develop encoding, barcoding, and library design strategies.
• Evaluate DNA-compatible chemistries and building blocks.
• Develop and optimize DEL selection methodologies and enrichment workflows.
• Refine NGS decoding and hit-deconvolution with Data Science.
• Collaborate with Biology, Biophysics, and Discovery Chemistry teams.

Kenntnisse

DEL library design

Encoding strategies

Selection methodologies

Hit triaging

DNA-compat chem

Collaborative mindset

NGS interpretation

Ausbildung

PhD in Chemistry/ Chemical Biology/ Medicinal Chemistry/ Synthetic Chemistry

Tools

NGS data analysis

Spotfire

Prism

SciFinder

Reaxys

PubMed

Jobbeschreibung

Monte Rosa Therapeutics, Inc. is seeking a highly motivated scientist to advance our DNA-encoded library (DEL) platform.

You will design next-generation DEL libraries, optimize encoding strategies, and refine selection methodologies to enable discovery of high-quality chemical starting points for challenging targets. Join a collaborative team interfacing Chemistry, Biology, Data Science, and Biophysics to accelerate drug discovery.