Associate Oligonucleotides Analytics

ITech Consult AG; Basel; On-site; CHF 90,000 - 110,000; Full time

Job summary

Roche in Basel seeks an Associate Oligonucleotides Analytics to perform routine oligonucleotide measurements, mainly HPLC with UV and MS detection, and to develop robust analytical methods under GxP guidelines.

You will plan and document experiments, work with Empower/OpenLab, and collaborate in a five-person team to ensure data quality for clinical supplies.

Qualifications

• Must have a vocational scientific qualification as chemical laboratory technician and 2–3 years of pharma industry experience.
• Hands-on experience with analytical instrumentation (HPLC, MS) and LC-MS is essential.
• Interest or background in analytical development for oligonucleotides is required.
• Good command of English; German skills are a plus.

Responsibilities

• Perform routine measurements for oligonucleotides (HPLC with UV and MS detection).
• Plan, execute, and document experiments with a team of five.
• Use Empower or OpenLab to control analytical instruments.
• Evaluate data with Genedata or Oligo Analysis Accelerator.
• Develop, improve, and validate analytical methods for oligonucleotides.
• Ensure compliance with GxP guidelines and SOPs.

Skills

HPLC

MS

LC-MS

Oligonucleotide analytics

GxP knowledge

Team player

Attention to detail

Education

Chemical laboratory technician qualification

Tools

Empower

OpenLab

Genedata

Oligo Analysis Accelerator

Job description

Background:

Background: Behind each product in clinical trials or sold by Roche is the involvement of Pharma Global Technical Operations. Pharma Global Technical Operations makes medicines with more than 10'000 employees at sites around the world. "Pharma Technical Development" is a global organization with over two thousand people dedicated to the development of new medicines to meet patients' needs. We actively collaborate and develop creative technical solutions to expertly deliver the pipeline and supply high quality products to patients. The group excels in its work through innovation, teamwork, dedication, and mutual respect and contributes every single day to bring new therapies to life and hope to patients. "Synthetic Molecules Technical Development" (PTDC) brings a broad range of experience across drug substance, drug product, and analytical sciences, and collaborates closely with partners in research and early development, Pharma Technical Development, and Commercial. PTDC is responsible for the technical development of our synthetic molecules pipeline and the manufacture of clinical supplies for clinical studies.
The position on offer is located in Analytical Research and Development for Synthetic molecules within Pharma Technical Development. Analytical Development for synthetic molecules is responsible for the development of resource and cost-efficient analytical methods by use of state of the art and innovative techniques such as high-performance liquid chromatography, gas or ion chromatography or mass spectrometry. The ultimate goal of our work is the development of a robust control strategy to release products for clinical trials, and finally for commercial supply.

The perfect candidate:

Has completed a vocational scientific qualification (e.g. apprenticeship, laboratory technician, Chemielaborant) and brings 2-3 years of experience in the pharmaceutical industry with a clear focus on analytical development for oligonucleotides or peptides. They offer strong hands-on expertise with HPLC, MS and ideally LC-MS, an excellent quality mindset with great attention to detail, and the ability to quickly adapt to new tools, ideas and agile ways of working while communicating confidently in English. This person should be motivated to focus on Lab Work.

Tasks & Responsibilities:

• Performing routine measurements for Oligonucleotides (mainly HPLC with UV and/or Single Quad MS detection)
• Planning, executing, and documenting experiments collaboratively in a team of five associates.
• Use chromatographic data systems like Empower or OpenLab to control analytical instruments.
• Evaluate data with Genedata or Oligo Analysis Accelerator
• Developing, improving, and validating analytical methods for the quality assessment of Oligonucleotides.
• Ensuring compliance with GxP guidelines and relevant SOPs.

Must Haves:

• A vocational scientific qualification as chemical laboratory technician (e.g. apprenticeship) with at least 2-3 years' experience in the pharmaceutical industry (No Studies Degree; No Master or PhD) (***** )
• Hands-on experience with analytical instrumentation and techniques (e.g., HPLC, MS) (***** )
• Interest or background in analytical development for oligonucleotides (***** )
• Strong knowledge of LC-MS applications and instruments is a plus
• Experience with large molecules/biologics analytics is an advantage
• Self-motivated, proactive, open-minded, goal-oriented, and a strong team player
• Stringent quality mindset, excellent attention to detail, and knowledge of GxP requirements across clinical phases.
• Good command of English; German proficiency is beneficial.

Reference Nr.: 925341
Rolle: Associate Oligonucleotides Analytics
Industrie: Pharma
Location:Basel
Pensum: 100%
Start: ASAP (01.12.2026)
Duration: 12+ Months
Deadline: 27/10/2026