Senior Research Scientist, Method Development (LC-MS)

Altasciences; Laval; On-site; CAD 90,000 - 120,000; Full time

Benefits offered by this job

Health/Dental/Vision Insurance Plans

401(k)/RRSP with Employer Match

Paid Vacation and Holidays

Paid Sick and Bereavement Leave

Employee Assistance & Telehealth

Training & Development Programs

Employee Referral Bonus Program

Annual Performance Reviews

Job summary

Altasciences in Laval, QC seeks a Senior Research Scientist with deep expertise in bioanalytical LC-MS/MS to lead development and optimization of regulatory-ready methods across small molecules, peptides, biologics, biomarkers, and oligonucleotides.

The role involves developing robust LC-MS/MS methods, overseeing sample prep and data interpretation, and guiding method transfer with validation and operations teams.

Qualifications

• Advanced knowledge of LC-MS/MS method development in regulated environments.
• Experience with sample preparation techniques (PPT, SPE, immunoaffinity, enzymatic digestion).
• Strong report writing and presentation abilities.
• Ability to work independently and lead projects.

Responsibilities

• Develop and optimize LC-MS/MS bioanalytical methods compliant with regulations.
• Oversee sample prep, analysis, and data interpretation to meet timelines.
• Troubleshoot complex bioanalytical challenges with systematic design.
• Engage in client discussions and scientific meetings sharing results.
• Prepare and review method development reports and SOPs.
• Collaborate with validation and operations for method transfer.

Skills

Bioanalytical method development

LC-MS/MS analysis

Data interpretation

Scientific writing

Project leadership

Education

Master’s degree in Biochemistry / Chemistry / Analytical Chemistry

PhD in a related field

Tools

LC-MS/MS instruments

Job description

About The Role

We are seeking a highly motivated and experienced Senior Research Scientist with strong expertise in bioanalytical mass spectrometry to join our Method Development team. The successful candidate will lead the development and optimization of regulatory-ready bioanalytical methods using liquid chromatography-mass spectrometry (LC-MS/MS) for a variety of therapeutic modalities, including small molecules, peptides, biologics, biomarkers, and oligonucleotides.

What You’ll Do Here

• Develop and optimize robust bioanalytical methods using LC-MS/MS in compliance with regulatory standards.

• Perform and oversee sample preparation, analysis, and data interpretation while meeting project timelines and quality expectations.

• Investigate and resolve complex bioanalytical challenges through systematic troubleshooting, experimental design, and root‑cause assessment.

• Participate in client discussions and scientific meetings, communicating method development strategies, analytical results, and technical recommendations.

• Prepare, review, and approve method development reports, SOPs, and other technical documentation as required.

• Collaborate with validation and operational teams to support successful method transfer and implementation.

• Stay current with advancements in LC-MS technologies and best practices to support continuous improvement.

• Adhere to Health and Safety protocols, including personal protective practices and laboratory upkeep.

What You’ll Need to Succeed

• Master’s or Ph.D. in Biochemistry, Chemistry, Analytical Chemistry, or a related discipline; a Bachelor’s degree with significant relevant experience may also be considered.

• Typically 5‑8+ years of relevant experience in LC‑MS/MS bioanalysis, with demonstrated experience independently leading bioanalytical method development projects.

• Experience in sample preparation techniques appropriate to the analyte type (e.g., protein precipitation, solid‑phase extraction, immunoaffinity‑based approaches, enzymatic digestion).

• Strong scientific writing, communication, and presentation skills, with the ability to effectively communicate complex technical concepts to both scientific and non‑scientific stakeholders.

Altasciences strives to provide a French work environment for its employees in Quebec. Altasciences has taken all reasonable measures to avoid imposing the above language requirement. This requirement is essential for the position of Senior Research Scientist, Method development (LCMS) in particular, but without limitation, for the following reason(s):

• The requirement to have study protocols read and documented in English as required by industry regulatory agencies

What We Offer

Altasciences offers a wide variety of benefits to help our employees live healthy and fulfilling lives both at and outside of work.

Altasciences’ Benefits Package Includes:

• Health/Dental/Vision Insurance Plans

• 401(k)/RRSP with Employer Match

• Paid Vacation and Holidays

• Paid Sick and Bereavement Leave

• Employee Assistance & Telehealth Program

Altasciences’ Incentive Programs Include:

• Training & Development Programs

• Employee Referral Bonus Program

• Annual Performance Reviews