Process Development Scientist

Polymorphic Biosciences Inc.; Vancouver; On-site; CAD 96,618 - 138,026; Full time

Benefits offered by this job

Comprehensive medical and dental coverage after 3 months

Opportunities for professional growth and development

Collaborative and innovative research environment

Job summary

A biotech research incubator in Vancouver is seeking a Process Development Scientist to lead lipid nanoparticle formulation and process development. The role requires hands-on expertise and strong communication skills. Candidates should have an MSc or PhD and 3+ years in industry. Responsibilities include owning experimental programs, establishing workflows for scale-up, and effectively communicating findings. The position offers a salary range of $70k - $100k, along with comprehensive medical benefits and opportunities for professional growth.

Qualifications

• 3+ years of relevant industry experience.
• Hands-on experience in lipid nanoparticle formulation.
• Familiarity with cGMP concepts and regulatory considerations.

Responsibilities

• Serve as the technical lead for LNP formulation and TFF process development.
• Establish and maintain the analytical characterization workflow for LNP quality attributes.
• Build the process knowledge base — defining critical process parameters and reproducibility boundaries.
• Develop documentation and workflows for scale-up and technology transfer.
• Communicate findings clearly to stakeholders and partners.
• Contribute to the broader R&D program as priorities evolve.

Skills

LNP formulation

Tangential flow filtration

Process development

Quality by Design (QbD)

Experimental design

Communication skills

Critical thinking

Education

MSc or PhD in chemical engineering or related field

Job description

Polymorphic Biosciences is a privately funded research incubator based in Vancouver, BC that explores novel applications of lipid nanoparticle technology. Our projects range from early-stage exploratory research to applied development for commercial applications.

Position Overview

As a Process Development Scientist, you will be responsible for generating the experimental data that drives our LNP manufacturing platform. This is a bench-heavy, independent role requiring hands‑on expertise in lipid nanoparticle formulation and tangential flow filtration. We are a small team building something new, and we need someone who brings both rigour and adaptability to the role.

Key Responsibilities

• Serve as the technical lead for LNP formulation and TFF process development, owning the experimental program from study design through to data analysis and reporting
• Establish and maintain the analytical characterization workflow for LNP quality attributes (particle size, PDI, encapsulation efficiency, yield)
• Build the process knowledge base — defining critical process parameters, operating ranges, and reproducibility boundaries
• Develop documentation and workflows to a standard that supports future scale-up and technology transfer into a cGMP environment
• Communicate findings clearly to both internal stakeholders and external partners through presentations, technical reports, and informal updates
• Contribute to the broader R&D program as priorities evolve

Knowledge and Qualifications

Required

• MSc or PhD in chemical engineering, pharmaceutical sciences, bioengineering, or a related field, with 3+ years of relevant industry experience
• Hands‑on experience in LNP formulation and tangential flow filtration
• Advanced technical knowledge in process development and Quality by Design (QbD) principles
• Strong experimental design skills with a systematic approach to process characterization
• Familiarity with cGMP concepts and regulatory considerations in the biotech/pharmaceutical industry
• Excellent written and verbal communication skills, with the ability to present technical findings to diverse audiences
• Strong critical thinking, attention to detail, and the ability to work independently in a developing environment

Preferred

• Direct experience working in or supporting a cGMP manufacturing environment
• Familiarity with RNA-based therapeutics (mRNA, siRNA)

What We Offer

• Salary range: $70k - $100k per annum
• Comprehensive medical and dental coverage after 3 months
• Opportunities for professional growth and development
• Collaborative and innovative research environment
• Contribution to cutting‑edge therapeutic development