Principal Bioinformatics Scientist: NGS & SBX Innovation

Roche; Mississauga; On-site; CAD 106,000 - 139,000; Full time

Job summary

Roche in Mississauga seeks a Principal Bioinformatics Scientist I to help define SBX-based sequencing workflows and collaborate across labs.

You will analyze raw data, prototype bioinformatic solutions, optimize pipelines, and work with wet-lab scientists and software engineers to advance molecular diagnostics.

PhD with 5+ years in biotech, strong Python and workflow tools (Nextflow or Snakemake) required, plus the ability to communicate complex results across disciplines.

Qualifications

• PhD in Bioinformatics, Computational Biology, or related field required.
• 5+ years of biotech industry experience.
• Experience solving complex library prep and chemistry challenges.

Responsibilities

• Sequence Data Diagnostics: trace data from raw signals to variant calling to assess analytical accuracy.
• Algorithm Deconstruction: evaluate core assumptions in open-source/internal tools and prototype solutions.
• Workflow Optimization: identify root causes of data anomalies to guide reagent formulation and pipeline improvements.
• Cross-Functional Collaboration: partner with wet-lab scientists, software engineers, and computational teams.
• R&D Leadership: serve as bioinformatics representative on cross-functional project teams.

Skills

Python

Nextflow

Snakemake

Problem solving

Education

Ph.D. in Bioinformatics

Tools

Linux

HPC

Job description

Roche in Mississauga seeks a Principal Bioinformatics Scientist I to help define SBX-based sequencing workflows and collaborate across labs.

You will analyze raw data, prototype bioinformatic solutions, optimize pipelines, and work with wet-lab scientists and software engineers to advance molecular diagnostics.

PhD with 5+ years in biotech, strong Python and workflow tools (Nextflow or Snakemake) required, plus the ability to communicate complex results across disciplines.