Postdoctoral Fellow (Research Institute)

McGill University Health Centre; Montreal; On-site; CAD 50,000 - 70,000; Full time

Job summary

Le Research Institute of the McGill University Health Centre (RI-MUHC) recherche un Postdoctoral Fellow en Biologie Cellulaire et Moléculaire. Le candidat retenu rejoindra le laboratoire de recherche orthopédique pour étudier les mécanismes du vieillissement et la dégénérescence tissulaire. Le poste implique de travailler sur des projets interdisciplinaires, comprenant des études de viabilité cellulaire, des analyses de données et le mentorat d'étudiants.

Qualifications

• Doit avoir un doctorat en Biologie Cellulaire et Moléculaire ou domaine connexe.
• Expérience en techniques de laboratoire telles que l'analyse des cellules et des molécules.
• Compétences en analyse de données et présentation des résultats attendue.

Responsibilities

• Concevoir et exécuter des tests cellulaires et moléculaires pour évaluer la sénescence.
• Analyser les données de criblage à haut débit et de RNA-seq.
• Contribuer à la préparation de manuscrits et à la présentation des résultats.

Skills

Cell isolation

Cell viability

Senescence assays

Transcriptomics

Proteomics

Immunochemistry

Behavioral analyses

Education

PhD in Cell and Molecular Biology or related field

Job description

RESEARCH INSTITUTE OF THE MUHC
The Research Institute of the McGill University Health Centre (RI-MUHC) is a world-renowned biomedical and hospital research centre. Located in Montreal, Quebec, the Institute is the research arm of the McGill University Health Centre (MUHC) affiliated with the Faculty of Medicine at McGill University. The RI-MUHC is supported in part by the Fonds de recherche du Québec - Santé (FRQS).

Introduction
Department / Research Program: Surgery / Surgical and Interventional Sciences (SIS)

The Research Institute of the McGill University Health Centre (RI-MUHC) is a world-renowned biomedical and hospital research centre. Located in Montreal, Quebec, the Institute is the research arm of the McGill University Health Centre (MUHC), affiliated with the Faculty of Medicine at McGill University.
We are seeking a talented and motivated Postdoctoral Fellow in Cell and Molecular Biology to join the Orthopaedic Research Laboratory under the supervision of Dr. Lisbet Haglund. The lab investigates mechanisms of aging and age-related tissue degeneration, with a specific focus on senescence, on the development of novel senolytic therapeutics, and on understanding their mode of action.
The fellow will be involved in an interdisciplinary project aimed at developing and characterizing optimized analogs of the senolytic compounds. These efforts will involve in vitro screening, and in vivo efficacy studies in mouse models. Techniques will include cell isolation, cell viability, senescence assays, transcriptomics, proteomics, immunochemistry, imaging (Microscopy, RNA scope), pharmacokinetics/pharmacodynamics profiling, and behavioral analyses.
Our lab is based at the RI-MUHC’s state-of-the-art facilities in Montreal, a multicultural hub of academic excellence and vibrant scientific exchange.

Responsabilities and Objectives
• Conduct and design cellular and molecular assays to assess senescence,
• Analyze and interpret high-throughput screening and RNA-seq data,
• Perform in vivo assessments of lead senolytic candidates in aged mouse models,
• Contribute to manuscript preparation and presentation of findings at conferences,
• Collaborate with a multidisciplinary team including chemists, pharmacologists, and bioinformaticians,
• Mentor graduate students and junior trainees as appropriate.