Post-doctoral researcher opportunity

Queen's University; Kingston; On-site; CAD 50,000; Full time

Job summary

An established industry player is seeking a passionate research candidate to explore small molecules for oncogenic protein regulation. This exciting role involves conducting cellular studies, improving chemical compounds, and assessing biophysical properties. The collaborative environment at a renowned university provides ample opportunities for professional development and networking within the Canadian research community. If you are eager to contribute to groundbreaking research and thrive in a multidisciplinary setting, this position offers an excellent platform for your career growth.

Benefits

Professionelle Entwicklung

Kommunikationsworkshops

Zugang zu wissenschaftlichen Netzwerken

Qualifications

• Robuste Expertise in organischer Synthese erforderlich.
• Erfahrung in molekularer oder zellulärer Biologie empfohlen.

Responsibilities

• Zellstudien der vielversprechendsten kleinen Regulatoren durchführen.
• Chemische Verbesserung von G4-Bindemitteln vornehmen.
• Biophysikalische Bewertung der Vorliebe zwischen G4-Strukturen.

Skills

organische Synthese

molekulare Biologie

biophysikalische Methoden

Kommunikationsfähigkeiten

Initiative

Job description

A collaboration between the groups of Dr. Petitjean (Chemistry) and Dr. Mulligan (Pathology and Molecular Medicine) is exploring a family of small molecules for the selective down-regulation of an important oncogenic proteins, taking advantage of the formation of guanine quadruplexes (G4s) in their gene promoter.

Responsibilities

The PDF candidate will mostly focus on (i) cellular study of the most promising small regulators, (ii) chemical improvement of G4 binders, and (iii) biophysical assessment of preference amongst G4 structures.

Qualifications

A robust expertise in organic synthesis is required. Some experience in molecular or cellular biology and biophysical methods are recommended.

Working at the interface between two groups, a strong sense of initiative and strong communication skills are important.

Environment

The research environment within Queen’s University is highly multidisciplinary and collaborative. This project bridges the departments of Chemistry, of Pathology & Molecular Medicine, and Chemical Engineering. Depending on progress and needs of the project, missions to the following sites may be envisaged: University of Toronto (drug formulation), University of Strasbourg, France (screening of responses in cancer cell lines), and Ecole Polytechnique,Palaiseau, France (advanced biophysics).

Professional Development is available at Queen’s University (Leadership, communication workshops) and through the Ontario Institute for Cancer Research (e.g. Bio-informatics for genomics, for proteomics, for RNA sequencing, or Machine Learning). The Canadian research community offers multiple venues for scientific exposure and networking.

The position is associated with an annual salary of CAD 50,000 plus benefits, for 1 year and a possible extension. It can start as early as April 2025. Candidates are invited to apply to Dr. Petitjean ([e-mail]) with a CV and a motivation letter.