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An exciting opportunity awaits you at a leading educational institution, where you will engage in groundbreaking research on small molecules targeting oncogenic proteins. This innovative project involves collaboration across multiple disciplines, providing a rich environment for professional growth and networking. You will focus on cellular studies, chemical enhancements, and biophysical assessments, while also benefiting from workshops and courses designed to enhance your skills. If you are passionate about research and eager to contribute to significant advancements in cancer treatment, this role is perfect for you.
2 days ago Be among the first 25 applicants
A collaboration between the groups of Dr. Petitjean (Chemistry) and Dr. Mulligan (Pathology and Molecular Medicine) is exploring a family of small molecules for the selective down-regulation of an important oncogenic proteins, taking advantage of the formation of guanine quadruplexes (G4s) in their gene promoter.
Responsibilities
The PDF candidate will focus on: (i) cellular studies of promising small regulators, (ii) chemical improvements of G4 binders, and (iii) biophysical assessments of preferences among G4 structures.
Qualifications
Robust expertise in organic synthesis is required. Some experience in molecular or cellular biology and biophysical methods is recommended.
Since the role involves collaboration between two groups, a strong sense of initiative and excellent communication skills are essential.
The research environment at Queen’s University is highly multidisciplinary and collaborative. This project bridges the departments of Chemistry, Pathology & Molecular Medicine, and Chemical Engineering. Depending on project progress, missions to sites such as the University of Toronto (drug formulation), University of Strasbourg, France (cancer cell line screening), and Ecole Polytechnique, Palaiseau, France (advanced biophysics) may be possible.
Professional development opportunities include leadership and communication workshops at Queen’s University and courses through the Ontario Institute for Cancer Research (e.g., bioinformatics, genomics, proteomics, RNA sequencing, machine learning). The Canadian research community offers numerous opportunities for scientific exposure and networking.
The position offers an annual salary of CAD 50,000 plus benefits, for 1 year with potential extension. The start date is as early as April 2025. Candidates should apply to Dr. Petitjean at anne.petitjean@chem.queensu.ca with a CV and motivation letter.