Post-Doctoral Fellowship in Structural Biology

European Commission; Brasil; Presencial; BRL 80.000 - 120.000; Tempo integral

Resumo da oferta

A leading research foundation in Brazil is offering a post-doctoral position focused on GRASP proteins, employing advanced methods like X-ray crystallography and Cryo-EM. The project aims at providing insights into GRASP's structural organization, essential for eukaryotic cell functions. This position promotes interdisciplinary training and is open to candidates of any nationality, located in Ribeirão Preto, São Paulo.

Serviços

FAPESP Post-Doctoral fellowship

Research contingency fund

Qualificações

• Experience with protein purification and heterologous expression required.
• Candidates must have a background in structural biology.
• Familiarity with research in unconventional protein secretion preferred.

Responsabilidades

• Study structural and dynamic properties of GRASP proteins using experimental methods.
• Collaborate with experts in crystallography and Cryo-EM.
• Conduct research in cell biology aligned with FAPESP PD objectives.

Conhecimentos

Molecular biophysics

Biochemistry

Cell biology

Formação académica

Postdoctoral qualification in relevant field

Ferramentas

X-ray crystallography

Cryo-electron microscopy

Descrição da oferta de emprego

Organisation/Company FAPESP - São Paulo Research Foundation Research Field Biological sciences Researcher Profile Established Researcher (R3) Country Brazil Application Deadline 15 Aug 2025 - 23:59 (UTC) Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The research plan for this post-doctoral position funded by the São Paulo Research Foundation (FAPESP) focuses on studying GRASP proteins, particularly their structural and dynamic properties. It involves a multi-faceted approach using several experimental methods, such as X-ray crystallography and Cryo-electron microscopy (Cryo-EM) to analyze GRASPs from different organisms (including human GRASPs), especially under conditions associated with unconventional protein secretion (UPS). GRASP proteins are essential for Types III and IV UPS in eukaryotic cells, and the structure of the Golgi apparatus. The project aims to provide insights into GRASP's structural organization, particularly the underexplored C-terminal SPR domain, which poses challenges due to its disordered nature.

Key objectives include obtaining high-resolution structural data, examining GRASP protein structure and dynamics, and exploring in vitro and in-cell structural behavior. Collaborations with experts in crystallography, Cryo-EM, and cell biology will support these goals. The project promotes interdisciplinary training in molecular biophysics, biochemistry, and cell biology, aligning with the FAPESP PD program's objectives to provide early-career researchers with a broad range of scientific expertise. Training in heterologous expression, protein purification, and X-ray crystallography or cryo-EM is required.

CV and a motivation letter should be sent to Antonio Costa ([e-mail] ), a Professor at the Department of Physics of the University of São Paulo's Ribeirão Preto Faculty of Philosophy, Sciences and Letters (FFCLRP-USP) in Brazil.

This opportunity is open to candidates of any nationality. The selected candidate will receive a FAPESP Post-Doctoral fellowship in the amount of R$ 12,000.00 monthly and a research contingency fund, equivalent to 10% of the annual value of the fellowship which should be spent on items directly related to the research activity.



More information about the fellowship is at: fapesp.br/oportunidades/8378 .

Eligibility of fellows: country/ies of residence:

• All

Eligibility of fellows: nationality/ies:

• All

Work Location(s)

Number of offers available 1 Company/Institute Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo (FFCLRP-USP) Country Brazil State/Province São Paulo City Ribeirão Preto Postal Code 14040-901 Street Av. Bandeirantes, 3900 (Departamento de Física)