Sr Scientist, Development Chemistry

Biopharma Careers; Beerse; Sur place; EUR 76 000 - 117 000; Plein temps

Avantages offerts par ce poste

Annual bonus

Vacation days

Parental leave

Résumé du poste

Johnson & Johnson in Beerse, Belgium, seeks a Sr. Scientist to design, develop and implement bioconjugation strategies for ADCs and other targeted therapeutics, driving site-selective conjugation technology and novel linker/payload approaches.

You will execute experimental plans to improve conjugation efficiency and manufacturability of bioconjugates, collaborating across functions and mentoring colleagues with scientific rigor.

Qualifications

• PhD or equivalent with research and development experience in relevant fields.
• Proven expertise in enzyme-based conjugation technologies and site-specific modification.
• Strong understanding of ADC design, including linkers, payloads, and conjugation strategies.

Responsabilités

• Design and implement bioconjugation strategies for ADCs and other targeted therapeutics.
• Develop site-selective conjugation technologies and assess enzymatic platforms.
• Plan experiments to optimize conjugation efficiency, linker attachment and payload incorporation.

Connaissances

Biocatalysis

Enzyme engineering

ADC design principles

Formation

PhD, postdoctoral or equivalent in organic chemistry/biochemistry/biology

Outils

LC-MS

HPLC

SEC

peptide mapping

Description du poste

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com .

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Chemical Research

Job Category:

Scientific/Technology

All Job Posting Locations:

Beerse, Antwerp, Belgium

Job Description:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

The department of Chemical Process Research & Development (CPRD) focuses on the development of synthetic methodologies and processes for small molecules, oligonucleotides, peptides and emerging modalities. We currently have open positionin the CPRD Development Chemistry group for a passionate Sr. Scientist in the field of Bio-conjugation.

As a Sr. Scientist you will be responsible fordesign, development, and implementation of bioconjugation strategies for ADCs and other targeted therapeutics. Help drive scientific innovation in site-selective conjugation technologies, including the evaluation of emerging enzymatic platforms. Design and execute experimental plans to optimize conjugation efficiency, linker attachment, payload incorporation, and product quality attributes related to platform development efforts aimed at improving manufacturability of bioconjugates.

Experience and skills

• PhD, postdoctoral, or equivalent by research and development experience in organic chemistry, biochemistry, biology or related field.
• Demonstrated expertise in enzyme-based conjugation technologies and site-specific protein modification.
• Strong understanding of ADC design principles, including antibodies, linkers, payloads, and conjugation strategies.
• Experience with protein characterization and related analytical techniques such as LC-MS, HPLC, SEC, peptide mapping, or related methods.
• Proficient in enzyme screening and engineering technologies for discovery and optimization of bioconjugation reactions.
• Ability to develop internal and external network of contacts and collaborators across functions, sites, and scientific disciplines.
• Proven track record of scientific excellence and successful research supported by peer-reviewed publications.
• Excellent oral and written communication skills, fluent in English both verbal and in writing.

Key Behaviors

• We strongly believe that the best science comes out of strong collaboration. Collaborative attitude to work in a multidisciplinary team with different backgrounds (education, gender, nationality, …) is a must!
• Passionate to work in the lab in close collaboration with other team members.
• Displays critical thinking and creativity in problem solving.
• Proactive in finding opportunities for improvement and open attitude towards new approaches.
• Mentors and develops colleagues in own areas of expertise and acts as a role model for others.
• Can challenge the status quo in a constructive manner.
• Excellent teammate which fosters new ideas and can create inclusive atmosphere.

Differentiating competencies

• Familiarity with developability assessments, manufacturability considerations, and CMC requirements for bioconjugates.
• Knowledge about the external landscape on emerging modalities and conjugation technologies.

Required Skills:

• Biocatalysis

Preferred Skills:

• Chemistry
• Collaboration
• Critical Thinking
• Data Quality
• Drug Discovery Development
• Emerging Technologies
• Execution Focus
• Industry Analysis
• Innovation
• Interdisciplinary Work
• Pharmaceutical Trends
• Pharmacognosy
• Pharmacology
• Quantitative Research
• Research Ethics
• Scientific Research
• Technologically Savvy

The anticipated base pay range for this position is:

€75,500.00 - €117,300.00

Benefits:

• In addition to base pay, we offer the following benefits*: an annual bonus with set target (% of pay) depending on pay grade / location, where the actual amount is based on the employees’ and companies’ performance of the previous calendar year, or sales commissions. Moreover, we offer vacation days, parental leave for a minimum of 12 weeks, bereavement leave, caregiver leave, volunteer leave, well-being reimbursement, programs for financial, physical and mental health. We also offer service anniversary and recognition awards, and subject to the terms of their respective plans, employees - and in some location’s eligible dependents - can participate in several insurance plans. For more information, visit Employee benefits | Supporting well-being & career growth | Johnson & Johnson Careers.
• *This is for informative purposes only.