Sr Scientist, Development Chemistry

7555-Janssen Pharmaceutica NV Legal Entity; Geel; Sur place; EUR 76 000 - 117 000; Plein temps

Avantages offerts par ce poste

Annual bonus

Vacation days

Well-being reimbursement

Résumé du poste

Johnson & Johnson is seeking a Sr. Scientist in Bio-conjugation within the CPRD Development Chemistry group in Beerse, Belgium.

You will design, develop, and implement bioconjugation strategies for ADCs and other targeted therapeutics, driving site-selective conjugation technologies and advancing manufacturability. The role requires a PhD or equivalent, expertise in enzyme-based conjugation, and strong analytical skills (LC-MS/HPLC/SEC).

Qualifications

• PhD, postdoctoral, or equivalent in organic chemistry, biochemistry, biology or related field.
• Demonstrated expertise in enzyme-based conjugation technologies and site-specific protein modification.
• Strong understanding of ADC design principles, including antibodies, linkers, payloads, and conjugation strategies.
• Experience with protein characterization and analytical techniques such as LC-MS, HPLC, SEC, peptide mapping.
• Proficient in enzyme screening and engineering for bioconjugation.
• Excellent oral and written communication skills in English.

Responsabilités

• Design, develop and implement bioconjugation strategies for ADCs and other targeted therapeutics.
• Drive scientific innovation in site-selective conjugation technologies across platforms.
• Plan and execute experiments to optimize conjugation efficiency, linker attachment and payload incorporation.
• Support manufacturability and quality attributes of bioconjugates.

Connaissances

Bioconjugation

Site-specific modification

ADC design principles

Protein characterization

LC-MS

HPLC

SEC

Enzyme screening

Communication skills

Formation

PhD or equivalent in organic chemistry/biochemistry/biology

Outils

LC-MS

HPLC

SEC

Peptide mapping

Description du poste

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow,and profoundly impact health for humanity.Learn more at jnj.com. As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function: Discovery & Pre-Clinical/Clinical Development job Sub Function: Chemical Research job Category: Scientific/Technology All Job Posting Locations: Beerse, Antwerp, Belgium

Job Description: Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine

The department of Chemical Process Research & Development (CPRD) focuses on the development of synthetic methodologies and processes for small molecules, oligonucleotides, peptides and emerging modalities. We currently have open position in the CPRD Development Chemistry group for a passionate Sr. Scientist in the field of Bio-conjugation. As a Sr. Scientist you will be responsible for design, development, and implementation of bioconjugation strategies for ADCs and other targeted therapeutics. Help drive scientific innovation in site-selective conjugation technologies, including the evaluation of emerging enzymatic platforms. Design and execute experimental plans to optimize conjugation efficiency, linker attachment, payload incorporation, and product quality attributes related to platform development efforts aimed at improving manufacturability of bioconjugates.

Experience and skills PhD, postdoctoral, or equivalent by research and development experience in organic chemistry, biochemistry, biology or related field. Demonstrated expertise in enzyme-based conjugation technologies and site-specific protein modification. Strong understanding of ADC design principles, including antibodies, linkers, payloads, and conjugation strategies. Experience with protein characterization and related analytical techniques such as LC-MS, HPLC, SEC, peptide mapping, or related methods. Proficient in enzyme screening and engineering technologies for discovery and optimization of bioconjugation reactions. Ability to develop internal and external network of contacts and collaborators across functions, sites, and scientific disciplines. Proven track record of scientific excellence and successful research supported by peer-reviewed publications. Excellent oral and written communication skills, fluent in English both verbal and in writing.

Key Behaviors

We strongly believe that the best science comes out of strong collaboration.

• Collaborative attitude to work in a multidisciplinary team with different backgrounds (education, gender, nationality, …) is a must!
• Passionate to work in the lab in close collaboration with other team members.
• Displays critical thinking and creativity in problem solving.
• Proactive in finding opportunities for improvement and open attitude towards new approaches.
• Mentors and develops colleagues in own areas of expertise and acts as a role model for others.
• Can challenge the status quo in a constructive manner.
• Excellent teammate which fosters new ideas and can create inclusive atmosphere.

Differentiating competencies

• Familiarity with developability assessments, manufacturability considerations, and CMC requirements for bioconjugates.
• Knowledge about the external landscape on emerging modalities and conjugation technologies.

#DPDS Required Skills

• Biocatalysis

Preferred Skills

• Chemistry
• Collaboration
• Critical Thinking
• Data Quality
• Drug Discovery Development
• Emerging Technologies
• Execution Focus
• Industry Analysis
• Innovation
• Interdisciplinary Work
• Pharmaceutical Trends
• Pharmacognosy
• Pharmacology
• Quantitative Research
• Research Ethics
• Scientific Research
• Technologically Savvy

The anticipated base pay range for this position is: €75,500.00 - €117,300.00

Benefits

• an annual bonus with set target (% of pay) depending on pay grade / location, where the actual amount is based on the employees’ and companies’ performance of the previous calendar year, or sales commissions.
• vacation days, parental leave for a minimum of 12 weeks, bereavement leave, caregiver leave, volunteer leave, well-being reimbursement, programs for financial, physical and mental health.
• service anniversary and recognition awards, and subject to the terms of their respective plans, employees - and in some location’s eligible dependents - can participate in several insurance plans.

For more information, visit Employee benefits | Supporting well-being & career growth | Johnson & Johnson Careers.

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow,and profoundly impact health for humanity.Learn more at https://www.jnj.com/.

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