Senior Scientist, High-Res MS for ADCs & tLNPs

Johnson & Johnson Innovative Medicine; Beerse; Sur place; EUR 80 000 - 138 000; Plein temps

Avantages offerts par ce poste

Hospital insurance

Health care incentives

Annual bonus

Résumé du poste

Johnson & Johnson Innovative Medicine in Beerse, Belgium, seeks a Senior/Principal Scientist with strong high-resolution mass spectrometry expertise in diverse therapeutic modalities to strengthen our AMA team. You will lead development of MS-based methods for ADCs and tLNPs and collaborate with internal and external experts to investigate process impurities and degradation products.

You will drive analysis method development, contribute to safety and regulatory compliance, and interact with R&D

Qualifications

• PhD in analytical chemistry or related field with 5+ years of relevant experience; or a master’s degree with 10+ years of experience. Working experience in pharmaceutical R&D is an asset.
• Proven in-depth and hands-on expertise in high-resolution mass spectrometry essential for MS-based structure elucidation of complex synthetic modalities
• Working experience with mass spectrometry of lipid nanoparticles, (cyclic) peptides, oligonucleotides and/or ADCs is a clear advantage
• Experience with coding, programming and the use of in silico tools to assist structure elucidation is a plus
• Hands-on experience with advanced hyphenated separation technology such as capillary electrophoresis (CE) or multidimensional liquid chromatography is an asset
• Knowledge of regulatory frameworks (e.g., ICH, EMA, FDA) and GMP guidelines, particularly concerning validation requirements, is an advantage
• Excellent English communication skills, both written and spoken, allowing for effective scientific discussions and collaboration.

Responsabilités

• Design and develop advanced (High Resolution) Mass Spectrometry-based methods for structure elucidation of diverse active pharmaceutical ingredients, with an emphasis on complex pharmaceutical modalities like ADCs and targeted lipid nanoparticle (tLNPs) components.
• Take the lead in the development of a comprehensive analytical toolbox for characterization of complex active pharmaceutical ingredients.
• Apply state-of-the art scientific knowledge to ensure high quality of the delivered results.
• Work in a multidisciplinary team of scientists and show the ability to learn and explore new analytical techniques.
• Maintain a safe work environment in compliance with all applicable environmental, health, regulatory requirements, GMP and safety regulations.
• Independently troubleshoot diverse mass spectrometers.
• Lead comprehensive root cause investigations related to MS-based structure elucidation of compounds within our R&D and commercial portfolio.
• Stay abreast with scientific knowledge to guarantee the delivery of high-quality results, strengthening our position as leaders in mass spectrometry-based structure elucidation.
• Initiate and lead partnerships with universities and other research institutions to expand our external innovation network, fostering collaboration that enhances our capabilities and expertise.

Connaissances

High‑resolution mass spectrometry

MS-based structure elucidation

Antibody-drug conjugates (ADCs)

Targeted lipid nanoparticles (tLNPs)

Analytical method development

Coding / in silico tools

GMP / regulatory familiarity

Excellent English communication

Formation

PhD in analytical chemistry or related field

Master's degree with 10 years of experience

Outils

Capillary electrophoresis

Multidimensional LC

In silico tools

Description du poste

Johnson & Johnson Innovative Medicine in Beerse, Belgium, seeks a Senior/Principal Scientist with strong high-resolution mass spectrometry expertise in diverse therapeutic modalities to strengthen our AMA team. You will lead development of MS-based methods for ADCs and tLNPs and collaborate with internal and external experts to investigate process impurities and degradation products.

You will drive analysis method development, contribute to safety and regulatory compliance, and interact with R&D