Postdoc: Brain Isoform Regulation & 3D Genomics

VIB BV; Antwerpen; Hybrid; EUR 42,000 - 54,000; Full time

Benefits offered by this job

Two-year contract with VIB/UAntwerp

Independent funding support

Training programs

International research environment

Access to core facilities

Job summary

VIB-UAntwerp Center for Molecular Neurology is seeking a postdoctoral scientist to study regulatory mechanisms of ATSS/ATTS choice in neurodegenerative diseases. The role bridges genetics, systems biology and computational biology with emphasis on isoform usage in dementia.

The project aims to build an isoform-specific regulatory atlas of the human brain, identify causal regulatory elements and transcription factors, and pinpoint putative disease isoforms with genetic underpinnings.

Qualifications

• PhD in computational biology, systems biology, bioinformatics or related disciplines.
• Strong computational background or hybrid with experimental training.
• Solid knowledge of single-cell data analysis and multimodal data integration.
• Strong understanding of gene regulatory mechanisms and 3D chromatin organization principles.
• Proficient in R and/or Python; excellent English communication.

Responsibilities

• Build isoform-specific regulatory atlas for human brain in health and disease.
• Identify causal regulatory elements and transcription factors underlying ATSS/ATTS choice in dementia.
• Identify putative disease-associated isoforms with genetic underpinnings and contribute to multidisciplinary analyses.

Skills

Single-cell analysis

Multimodal data integration

Gene regulatory mechanisms

3D chromatin organization

R and Python programming

English communication

Strong academic record

Education

PhD in computational biology or related

Tools

R

Python

Job description

VIB-UAntwerp Center for Molecular Neurology is seeking a postdoctoral scientist to study regulatory mechanisms of ATSS/ATTS choice in neurodegenerative diseases. The role bridges genetics, systems biology and computational biology with emphasis on isoform usage in dementia.

The project aims to build an isoform-specific regulatory atlas of the human brain, identify causal regulatory elements and transcription factors, and pinpoint putative disease isoforms with genetic underpinnings.