Piezoelectric Micromachined Ultrasound Transducer (PMUT) driven stem cell differentiation and n[...]

Imec India Private Limited; Vlaams-Brabant; Sur place; EUR 20 000 - 40 000; Plein temps

Résumé du poste

A leading research organization in Belgium seeks a candidate for a 6-month internship integrating PMUT technology with stem cell research. The role involves designing PMUT arrays, validating their effectiveness for nerve repair, and optimizing acoustic stimuli for neural tissue regeneration. Ideal applicants will possess a Master’s degree in Bioengineering or related fields and relevant engineering background.

Qualifications

• Background in electromechanical engineering or related fields.
• Familiarity with stem cell research and regenerative medicine.
• Experience in engineering principles and biomedical applications.

Responsabilités

• Design tailored PMUT arrays for enhancing stem cell differentiation.
• Validate PMUT effectiveness in nerve repair.
• Optimize acoustic stimuli for improved neural tissue outcomes.

Connaissances

Mechanical Engineering

Biomedical Engineering

Electromechanical Engineering

Nanotechnology

Formation

Master of Bioengineering

Master of Engineering Technology

Master of Science

Master of Engineering Science

Description du poste

/ Piezoelectric Micromachined Ultrasound Transducer (PMUT) driven stem cell differentiation and nerve regeneration for neural repair

Piezoelectric Micromachined Ultrasound Transducer (PMUT) driven stem cell differentiation and nerve regeneration for neural repair

Master projects/internships - Leuven | More than two weeks ago

Exploring the role of PMUTs in Regenerative and Personalized Medicine. Validate and characterize iPSC and Neural Stem cell differentiation and regeneration and enhancement using our unique PMUT technology platform.

Abstract: The interplay between mechanical forces and cellular behavior is a cornerstone of regenerative medicine, driving critical processes such as stem cell differentiation, tissue repair, and functional recovery. In recent years, this relationship has gained attention for its potential in nerve repair and neural tissue regeneration, especially using advanced ultrasonic technologies. Piezoelectric Micromachined Ultrasonic Transducers (PMUTs) have emerged as a transformative tool for delivering localized, high-frequency mechanical stimuli to cellular environments, enabling precise modulation of stem cell behavior and tissue repair.

This project proposes the design and application of tailored PMUT arrays to enhance stem cell differentiation and promote nerve repair through ultrasound-based stimulation. PMUT technology offers unparalleled control over biomechanical forces, allowing for non-invasive, spatially, and temporally precise delivery of acoustic energy. By leveraging these capabilities, we aim to influence cellular organization, enhance neural differentiation, and foster functional neural tissue repair.

Specifically, this work will validate PMUT arrays capable of generating finely tuned acoustic fields that interact with stem cells in engineered neural tissue models. The study will systematically explore how acoustic parameters such as frequency, amplitude, and pulse patterns modulate stem cell behavior—from promoting neuronal lineage commitment to enhancing integration and functionality of neural networks. Our platform’s flexibility will allow optimization of acoustic stimuli to support neural repair, reduce inflammation, and improve overall recovery outcomes.

Type of project: Combination of internship and thesis, Internship

Duration: 6 months

Required degree: Master of Bioengineering, Master of Engineering Technology, Master of Science, Master of Engineering Science

Required background: Electromechanical engineering, Nanoscience & Nanotechnology, Mechanical Engineering, Biomedical engineering, Bioscience Engineering, Other

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