Pharmacometrics Lead

1000scholars; Anderlecht; On-site; EUR 90,000 - 150,000; Full time

Job summary

UCB is seeking a Pharmacometrics Lead to define and deliver the pharmacometrics strategy for asset development. You will lead PBPK/QSP modeling and communicate insights to project teams across functions in Brussels or Anderlecht, Belgium.

Ideal candidates hold a PhD/MD in related fields, have 6+ years of modeling experience, and are proficient in PK-Sim/MoBi, SimCyp, and related tools. Strong collaboration with IT and regulatory teams is essential.

Qualifications

• PhD or MD in Pharmaceutical Sciences, Statistics or Engineering.
• 6+ years’ PBPK and QSP modeling experience in (Bio)pharma.
• Expertise in PK-Sim/MoBi, SimCyp, GastroPlus, MATLAB and R.
• Experience with ONMEM is a plus.
• Agile mindset with ability to prioritise multiple tasks.
• Outstanding communication and presentation skills.

Responsibilities

• Extrapolation, dose selection, trial design and PIP development.
• Perform hands-on PBPK, QSP and clinical trial simulations.
• Translate analyses into actionable project insights.
• Develop submission-ready pharmacometrics analysis plans/reports.
• Oversee outsourced pharmacometrics activities.
• Help build a team with state-of-the-art mechanistic approaches.
• Engage with regulatory authorities globally in pediatrics, neurology and immunology.
• Promote MID3 internally and externally.

Skills

PBPK Modeling

QSP Modeling

PK-Sim/MoBi

SimCyp

GastroPlus

MATLAB

R

Python

Regulatory insight

Education

PhD/MD in Pharmaceutical Sciences, Statistics or Engineering

Tools

PK-Sim

MoBi

SimCyp

GastroPlus

MATLAB

R

ONMEM

Python

Job description

Pharmacometrics Lead – UCB – Union Chimique Belge – Brussels or Anderlecht, Belgium

About the role

Leading and delivering the Pharmacometrics strategy to support development of our assets.

Who you’ll work with

Reporting to Global Head of Pharmacometrics you will be working closely with the QCP Leads assigned to the various projects, to ensure clear integration of the pharmacometrics aspects into the programs. Working with IT to ensure appropriate system validation and integration with other software is enabled.

What you’ll do

• Extrapolation (where appropriate), dose selection, trial design, PIP development and ongoing evaluation of data as generated;
• Performing hands‑on PBPK, QSP, and clinical trial simulations on an assigned project;
• Transform PBPK and QSP analyses into actionable insights and communicate these findings effectively to project teams and stakeholders;
• Developing submission‑ready fit for purpose Pharmacometrics analysis plans and reports;
• Initiating and overseeing outsourced pharmacometrics activities and further internalizing the work as needed;
• Supporting the development of a team from both a technical and scientific perspective to ensure state of the art mechanistic approaches are applied to optimize drug discovery and development;
• Having a working knowledge about the regulatory pathways on a global basis and opportunities for collaboration with health authorities (either through working parties, advice meetings, and other initiatives) in pediatrics, Neurology and Immunology;
• Promoting MID3 internally and externally.

Interested? For this role you will need the following education, experience and skills

• Doctorate (PhD or MD) in the related disciplines of Pharmaceutical Sciences, Statistics or Engineering;
• 6+ years’ experience in PBPK and QSP modeling in (Bio)pharmaceutical industry;
• Expertise in PK‑Sim®/MoBi®, SimCyp®, GastroPlus®, MatLab and R. ONMEM and python is an additional advantage;
• Experience in population PK/PD modeling is a plus;
• Agile mindset with a proven ability to adjust by prioritizing multiple tasks;
• Outstanding communication, organizational and presentation skills.