Associate Research Grade Production

eTheRNA Inc.; Niel; On-site; EUR 42,000 - 62,000; Full time

Benefits offered by this job

Insurance package

Meal vouchers

Eco vouchers

Bike leasing

Benefits at work

Job summary

eTheRNA immunotherapies seeks an Associate Research Grade Production based in Niel, Belgium, to produce research-grade mRNA-LNPs and manage lipid stock, encapsulation, and purification. The role collaborates with MRNA production, QC and Process Development teams to optimize formulation processes.

The candidate will perform in-process characterization and ensure documentation, batch records and reporting of results.

Qualifications

• Experience with production of mRNA-LNPs and related formulations.
• Familiarity with QC methods for nanoparticle characterization.
• Ability to work in cross-functional teams and document results clearly.

Responsibilities

• Produce research grade mRNA-LNPs including lipid stock preparation and encapsulation.
• Perform in-process and release characterization of LNP formulations (size, zeta, encapsulation).
• Prepare, aliquot and store LNP batches and monitor stability.
• Assist optimization and scale-up with mRNA production, QC, and Process Development.

Skills

mRNA production

LNP formulation

Quality control

Analytical skills

Lab teamwork

Sterile technique

DLS

RiboGreen

HPLC

Tools

DLS

RiboGreen

HPLC

Sterile filtration

Job description

etherna providesresearch and manufacturing excellenceby teaming up with highly skilled scientists, researchers and technical experts who are recognized for their contributions to the industry. We acquired substantial intellectual propertyand know-howover the years thatsupport ourexceptional leadership in mRNA and LNP innovation. With a careful balance in our skillset, state-of-the-art facilities and specialized equipment we tackle complex challenges and assure efficiency in our operations. www.etherna.be | www.ethernamanufacturing.com

The Associate Research Grade Production is a hands-on person who will work collaboratively on the production of mRNA and lipid nanoparticles (LNPs), covering mRNA production, lipid stock preparation, mRNA encapsulation, purification, concentration and characterization of the resulting formulations.

This position reports to the Manufacturing Manager and will be based in Niel, Belgium.

Job requirements

The Associate Research Grade Production’s duties shall include, but not be limited to:

• Primary responsibility will be to produce research grade mRNA-LNPs, including lipid stock preparation, mRNA encapsulation (e.g., microfluidic mixing), buffer exchange/purification, concentration and sterile filtration.
• Perform in-process and release characterization of LNP formulations (e.g., particle size and polydispersity by DLS, zeta potential, encapsulation efficiency and mRNA content by RiboGreen assay, pH and osmolality).
• Prepare, aliquot and store LNP batches under appropriate conditions and follow up on their stability.
• Execute new techniques/assays and support the optimization and scale-up of formulation processes. Work collaboratively with other departments (mRNA production, QC, Process Development) and/or project managers.
• Maintain appropriate files related to ongoing formulations. Write formulation protocols, batch records, analytical test methods and reports if necessary.
• Keep track of QC results of ongoing productions.
• Troubleshoot experimental techniques, analyze the data and report the experimental results.
• Participate in the maintenance, calibration and cleaning of formulation equipment and lab areas.
• Inventory management and ordering of lipids, consumables and laboratory supplies in close collaboration with the Supply Chain Coordinator.

Our offer

An exciting job in a dynamic and entrepreneurial environment with room for personal development.

Work within an innovative environment that will give you the resources to extend your knowledge.

Employment contract of unlimited duration with a competitive salary package. (insurance package, meal vouchers, eco vouchers, possibility to lease a bike, benefits at work ...)

Working in a fun team where collaboration, growth but above all fun are central.

While we appreciate the interest, we’re not engaging with external recruiters for this position.