Senior Technical Officer

Centre for Continuing Education; Sydney; On-site; AUD 117,000 - 128,000; Full time

Job summary

University of Sydney is seeking a Senior Technical Officer to support the ACRF Single-Cell Cancer Proteomics Laboratory. You will provide specialized technical expertise and oversee advanced mass spectrometry and LCMS workflows across cutting-edge platforms.

You will train users, ensure safety, maintain instruments such as LMD7, cellenONE, and Orbitrap Astral Zoom, and contribute to high-quality research outcomes in a collaborative environment.

Qualifications

• Bachelor's degree in a relevant scientific discipline or equivalent experience.
• PhD in biomedical research with MS-based Omics is advantageous
• Experience with LCMS workflows in proteomics/metabolomics/lipidomics.

Responsibilities

• Provide expert technical advice and perform experiments with researchers and staff.
• Oversee operation, optimization and maintenance of lab instrumentation.
• Support single-cell proteomics and related workflows across a multi-user facility.
• Train researchers, students, staff and visitors in safe use of equipment.
• Perform risk assessments and develop safe work procedures.
• Manage technical information requests and quotations for fee-for-service activities.
• Analyze data and contribute to reporting and documentation.
• Coach users and maintain a collaborative lab environment.
• Ensure WHS compliance and maintain a clean lab environment.

Skills

LCMS research

Mass spectrometry operation

Nanoflow LC

Orbitrap instruments

Multi-user lab coordination

Technical training

Data analysis in R

Education

Bachelor's degree in a relevant scientific discipline

PhD in biomedical research (Omics)

Tools

LMD7 microscope

cellenONE single cell sorter

Orbitrap Astral Zoom MS

Job description

Senior Technical Officer University of Sydney Sydney, NSW, AU

Job Description

Base Salary $117,133 - $127,610 + 17% superannuation

About the opportunity

Sydney Mass Spectrometry (SydneyMS) is a core research facility within the DVC Research Portfolio, providing a suite of over 20 state‑of‑the‑art mass spectrometers. SydneyMS supports research with global impact in the areas of metabolomics, lipidomics, proteomics, and mass spectrometry imaging. The facility provides best in class services to internal and external clients to the University, including industry, and across a wide range of disciplines in medical and life sciences.

Key responsibilities

As the Senior Technical Officer, you will play a key role in supporting the ACRF Single‑Cell Cancer Proteomics Laboratory. The laboratory has been equipped with a comprehensive set of equipment for single cell analysis including a LMD7 microscope, a cellenONE single cell sorter, and an Orbitrap Astral Zoom mass spectrometer. You will be providing specialist technical expertise, operational oversight and advanced scientific support across these cutting‑edge single‑cell proteomics platforms.

Working within a collaborative research environment, you will oversee laboratory operations, undertake experimental work, support research projects, train users and researchers, and maintain sophisticated instrumentation. You will contribute to the delivery of high‑quality research outcomes while ensuring laboratory activities are conducted safely, efficiently and in accordance with University requirements.

• provide expert technical advice and undertake experiments in collaboration with researchers and technical staff
• oversee the operation, optimisation and maintenance of laboratory instrumentation and equipment
• support single‑cell proteomics and related research workflows across a multi‑user facility
• train researchers, students, staff and visitors in the safe and effective use of laboratory equipment and techniques
• perform risk assessments and develop safe work and maintenance procedures for laboratory operations
• manage technical information requests, quotations and support for fee‑for‑service and contract research activities
• analyse and interpret experimental data and contribute to scientific reporting and technical documentation
• coach and mentor users while contributing to a collaborative and high‑performing laboratory environment
• ensure compliance with work health and safety requirements and maintain a clean, safe laboratory environment

About you – Required

• demonstrated experience supporting or undertaking LCMS research within proteomics, metabolomics, lipidomics
• proven experience operating, troubleshooting, optimising and maintaining mass spectrometry and/or liquid chromatography instrumentation, particularly nanoflow LCs and orbitrap mass spectrometers within life or medical sciences research settings
• experience working within a multi‑user laboratory environment, including vendor liaison and equipment coordination
• demonstrated ability to deliver specialised technical training and support to other researchers, users and staff
• strong analytical, problem‑solving and organisational skills, with the ability to manage competing priorities
• excellent written and verbal communication skills and the ability to build effective stakeholder relationships
• a bachelor's degree in a relevant scientific discipline, or an equivalent combination of training and experience

• demonstrated experience supporting or undertaking LCMS research within proteomics, metabolomics, lipidomics, for single‑cell and/or spatial omics analysis
• knowledge and practical experience in optical light microscopy, especially in the area of laser capture microdissection
• knowledge and practical experience in cell sorting and flow cytometry
• knowledge and practical experience in data analysis and data visualisation, especially in the use of R
• a PhD in biomedical research that was heavily based on mass spectrometry‑based Omics analysis

Sponsorship / work rights for Australia

You must have unrestricted work rights in Australia for the duration of this employment to be eligible to apply. Visa sponsorship is not available for this appointment.

Pre‑employment checks and declarations

Your employment is conditional upon the successful completion of all pre‑employment or background checks required for the role in accordance with satisfactory standards to the University. Also, to meet the University's obligations under the National Higher Education Code to Prevent and Eliminate Gender‑Based Violence you will be asked to declare if you have been investigated for, or found to engaged in, sexual harm or gender‑based violence in the course of previous employment or in a legal process. Similarly, your ongoing employment is conditional upon the satisfactory maintenance of all relevant clearances and background check requirements. If you do not meet these conditions, the University may take any necessary step, including the termination of your employment.

EEO statement

At the University of Sydney, our shared values are trust, accountability and excellence and we strive to be a place where everyone can thrive. We are committed to creating a University community that thrives through diversity and reflects the wider community that we serve.

We deliver on this through our commitment to diversity and inclusion, evidenced by our people and culture programs, as well as key strategies to increase participation and support the careers of Aboriginal and Torres Strait Islander People, women, people living with a disability, people from culturally and linguistically diverse backgrounds, and those who identify as LGBTQIA+.

We welcome applications from candidates from all backgrounds. We are proud to be recognised as an Australian Workplace Equality Index (AWEI) Platinum Employer. Find out more about our work on diversity and inclusion.

Applications Close Monday 05 October 2026 11:59 PM

The University reserves the right not to proceed with any appointment.

The University of Sydney may conduct routine pre‑employment checks before an appointment is made.

For a confidential discussion about the role, or if you require reasonable adjustment or any documents in alternate formats, please contact Kale Claffey Recruitment Operations by email to [e-mail]

Want to know more about working at the University of Sydney? https://www.sydney.edu.au/about-us.html