Scientist I – Molecular Biology

One Nucleus Ltd; Town of Cambridge; On-site; AUD 86,000 - 95,000; Full time

Benefits offered by this job

25 annual leave days

Education stipend

Equity compensation

Private Medical Insurance

Pension contribution matching

Job summary

Alloy Therapeutics is seeking a Scientist I – Molecular Biology to join the GEO team at their Cambridge site. The role focuses on designing and constructing large-scale synthetic gene loci for next-generation discovery platforms, using advanced genome engineering to enable diverse therapeutic antibody discovery, including bispecifics and VHHs.

The position blends thoughtful genetic design with hands-on wet-lab work.

Qualifications

• PhD in Developmental Biology, Functional Genetics, Molecular Biology, Immunology, Cell Biology or related field, or equivalent experience.
• Immunology knowledge and ability to perform immunophenotypic analysis with multicolor flow cytometry.
• Familiarity with genetic engineering and transgenic models; design of targeting and screening strategies.

Responsibilities

• Design and construct complex gene loci to support antibody discovery platforms.
• Perform hands-on genome engineering and model development to support generation of therapeutics.
• Ensure data quality through rigorous analysis and meticulous documentation.

Skills

CRISPR/Cas9

Immunology

Molecular biology

Flow cytometry

Genetic engineering

Animal models

NGS

V(D)J recombination

Education

PhD in Developmental Biology or related

Tools

Geneious Prime

Benchling

FlowJo

Job description

Scientist I – Molecular Biology
Location: Cambridge, UK (on-site)
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The Company

We are Alloy Therapeutics — a biotechnology ecosystem and Product Development Organization (PDO) empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. May the Best Drug Win.

Alloy has evolved from a startup into a global product development organization operating 11 divisions across 5 research sites in 4 countries on 3 continents. Our model - Integrated Independence - combines centralized capabilities with entrepreneurial operating divisions. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.
At Alloy, we have an ethos of "Mentorship-By-Apprenticeship" in all of our positions. We strive to have workers in the office when needed to interact organically and face-to-face. Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year. We respect and value our colleagues for their hard work that requires them to be in the lab every day. We ask our people who have more flexible accommodations to appreciate their colleagues who have less flexibility. We are all one team!

About the Role at Alloy Therapeutics

As a Molecular Biologist in the GEO (Genetically Engineered Organisms) Team, you will contribute to the design and construction of large-scale synthetic gene loci that underpin our next-generation discovery platforms. Using advanced genome engineering approaches, you will help create highly diverse systems for therapeutic antibody discovery, including bispecifics and VHHs. This role blends thoughtful genetic design with hands-on experimental work to build the scientific capabilities that enable our partners to develop new medicines.
You will utilise the latest technologies and equipment to develop and characterize next-generation research models, supporting the discovery of innovative therapeutics and helping others make better medicines.

How You’ll Drive Impact

• Complex Locus Engineering: Design and implement complex humanization strategies using state-of-the-art technologies to model the human immune repertoire across diverse research platforms.
• Quality Control: Apply rigorous scientific judgment to ensure consistency and reliability by critically evaluating data, experimental approaches, and conclusions.
• Innovation: Approach scientific challenges with curiosity and an open mindset, contributing new ideas and methods while fostering collaborative problem-solving.
• Execution: Take initiative and proactively advance work, demonstrating ownership and accountability while contributing to team success.
• Collaboration & Trust: Build strong working relationships by consistently delivering high-quality work, acting with integrity, and supporting shared team goals.

Required Qualifications

• Education: PhD in Developmental Biology, Functional Genetics, Molecular Biology, Immunology, Cell Biology or a related discipline, or equivalent industry experience (your title will be aligned with your experience).
• Immunology: Knowledge of immunology and the ability to perform immunophenotypic analysis of B and T cell populations using multicolor flow cytometry.
• Genetic Engineering: Familiarity with genetic engineering and the generation of transgenic animal models, including the design of targeting and screening strategies, vector construction and preparation, data analysis and troubleshooting.
• Precision Genome Engineering: Proficiency in CRISPR/Cas9 and advanced integration tools, such as Recombinase-Mediated Cassette Exchange (RMCE) or site‑specific integrases (e.g., Bxb1).
• Molecular Biology: High proficiency in molecular biology techniques such as PCR, western blotting, next‑generation sequencing (NGS), plasmid construction and nucleic acid purification.
• Comparative Immunogenetics: A good understanding of human immunology and repertoire generation mechanisms across different species, specifically how to engineer for both V(D)J recombination and alternative diversification strategies like gene conversion or somatic hypermutation.
• Model Characterization: Experience with the functional validation of new in vivo models, including flow cytometry, cell sorting, and the assessment of serum titers/binder affinity.
• Animal Science: Foundational knowledge of animal physiology, husbandry, and genotyping.
• Software: Working knowledge of, and the ability to quickly learn, software packages such as Geneious Prime, Benchling and FlowJo.

How You Work

• Accountability & Drive: You thrive in a nimble, startup-style environment, owning projects from the initial "dry lab" design to the final "wet lab" validation.
• Attention to Detail: You apply meticulous attention to detail in scientific thinking and written documentation, and communicate and present information with clarity and precision.
• Proactive Approach: You are eager to learn and support the team, bring an independent sense of urgency, and drive projects forward through persistence and a commitment to integrity.

Why This Role Is Unique

You will join the Genetically Engineered Organisms (GEO) team and work alongside the broader Alloy ecosystem, including our Antibody Division, 82VS, Bioinformatics, and our extensive network of partners and collaborators. Our team's goal is to develop innovative transgenic platforms to support antibody discovery efforts both internally and for our external partners, ultimately delivering the best medicines to patients.
We are a small, diverse team bringing together a wide range of expertise in genetics, molecular biology, and cellular biology. By working closely with internal colleagues and external partners, we develop next-generation platforms that drive drug discovery research.
Supported by various functional groups and a strong network of collaborators and consultants, the GEO team thrives in a highly collaborative, multidisciplinary environment.

Taking Care of Our People

We support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you’re single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.

Compensation

• Competitive base and equity compensation commensurate with level of experience and independence

Health & Wellbeing

• Comprehensive benefit package including Private Medical Insurance, pension contribution matching, and mental health and wellbeing support

Unique Perks

• 25 annual leave days (with one additional day for every 3 years completed, up to 27 days)
• Annual stipend for continuing education with commitment to your career through an individualized professional development plan

Pay Transparency

At Alloy Therapeutics, we believe in fostering trust and open communication. For this role, the estimated salary range is £45,000–£50,000, with the final offer based on factors like your experience, skills, and alignment with our needs. Additionally, this role is eligible for equity compensation, reflecting our commitment to shared success as we work together to make better medicines. We are proud to offer competitive compensation and benefits, aiming to support our team’s professional and personal well‑being. If you have any questions about pay or benefits, we’re here to help.

Alloy Therapeutics is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, disability, or other legally protected status. If you are unable to submit an application because of incompatible assistive technology or a disability, please contact us at [e-mail] . We will make every effort to respond to your request for disability assistance as soon as possible.