fall 2026

IMP; Wien; Vor Ort; EUR 13.000 - 20.000; Vollzeit

Benefits dieser Stelle

Monthly stipend

Zusammenfassung

The Plaschka lab at the Research Institute of Molecular Pathology (IMP) in Vienna is offering a Master’s student position to study a key step in human mRNA processing. The successful candidate will work on an essential multi-subunit complex and gain hands-on experience with cloning, purification, structure determination by cryo-electron microscopy, and functional assays.

The ideal applicant is highly motivated with an interest in structural biology and experience in standard biochemistry

Qualifikationen

• Strong interest in structural biology.
• Experience with standard biochemistry methods is required.
• Enrolled in a Master’s program related to molecular biology or biochemistry.

Aufgaben

• Carry out research on a key multi-subunit complex involved in mRNA processing.
• Perform cloning and purification of the complex from insect cells.
• Determine structure by cryo-EM and conduct functional assays.

Kenntnisse

Interest in structural biology

Biochemistry techniques

Cryo-EM exposure

Ausbildung

Master's student in a relevant field

Tools

Cryo-EM

Cloning

Protein purification

Jobbeschreibung

The Plaschka lab has an open position for a Master’s student at the Research Institute of Molecular Pathology (IMP) to study a key step in human mRNA processing.

The successful candidate will carry out research on an essential multi-subunit complex involved in mRNA processing. He/she will be exposed to a variety of molecular biology techniques, including biochemical preparation of the complex from insect cells (cloning, purification), structure determination by cryo-electron microscopy (cryo-EM), and functional assays.

The ideal applicant will be highly motivated, have a strong interest in structural biology and have experience in standard biochemistry methods. We offer an exciting research project, outstanding infrastructure, and an excellent opportunity to learn both biochemistry and cryo-EM. The position is available from fall 2026and remains open until filled. The student will receive a monthly stipend.

• Vorländer, M. K.,Rothe, P., Kleifeld, J., Cormack, E., Veleti, L., Riabov-Bassat, D., Fin, L., Phillips, A. W., Cochella, L., Plaschka, C. (2024): Mechanism for the initiation of spliceosome disassembly. Nature.
• Pacheco-Fiallos, B., Vorländer, MK., Riabov-Bassat, D., Fin, L., O'Reilly, FJ., Ayala, FI., Schellhaas, U., Rappsilber, J., Plaschka, C. (2023) mRNA recognition and packaging by the human transcription-export complex. Nature.
• T. Pühringer*, U. Hohmann*, L. Fin, B. Pacheco-Fiallos, U. Schellhaas, J. Brennecke, C. Plaschka. Structure of the human core transcription-export complex reveals a hub for multivalent interactions. eLife (2020) 9, e61503. *Equal contribution.
• C. Plaschka*#, P.-C. Lin*#, C. Charenton, K. Nagai#. Prespliceosome structure provides insight into spliceosome assembly and regulation. Nature (2018) 558, 419-422. *Equal contribution. #Co-corresponding authors.
• C. Plaschka*#, P.-C. Lin*#, K. Nagai#. Structure of a pre-catalytic spliceosome. Nature (2017) 546, 617-621. *Equal contribution. #Co-corresponding authors.