Senior Bioinformatician

M42 Ltd.; Abu Dhabi; Sur place; AED 350 000 - 600 000; Plein temps

Résumé du poste

M42, headquartered in Abu Dhabi, seeks a senior bioinformatician to lead the design and execution of analyses on large-scale human genomic datasets, including whole genome sequencing. You will integrate genomic data with clinical phenotypes and develop robust workflows, collaborating with scientists, clinicians, and technical teams, and contributing to publications.

Ideal candidates hold a PhD in Bioinformatics or related field, with extensive experience in human genomics, Python/R and tools

Qualifications

• PhD in Bioinformatics, Genomics, or related field or equivalent.
• Extensive experience in human genomics, bioinformatics, computational biology, or biomedical data science.
• Strong publication record preferred.
• Proficiency in Python and/or R.
• Hands-on experience with PLINK, REGENIE, bcftools, VCFtools or equivalents.

Responsabilités

• Lead design and execution of bioinformatics analyses on large-scale human genomic datasets (WGS).
• Analyze and interpret genomic findings in context of genetics and phenotypes.
• Develop and optimize bioinformatics workflows and pipelines.
• Collaborate with multidisciplinary teams to deliver research objectives.
• Contribute to publications, manuscripts, and presentations.
• Communicate methods and results to diverse stakeholders.
• Ensure compliance with data governance and scientific best practices.

Connaissances

Python

R

Bioinformatics tools

Genomics

Formation

PhD in Bioinformatics/Genomics

Outils

PLINK

REGENIE

bcftools

VCFtools

Description du poste

Overview

M42 is a global health champion powered by artificial intelligence (AI), technology and genomics to advance innovation in health for people and the planet. Headquartered in Abu Dhabi, M42 combines its specialized, state-of-the-art facilities with integrated health solutions like genomics and biobanks, and harnesses advanced technologies to deliver precise, preventive and predictive care, to disrupt traditional healthcare models and positively impact lives globally.

Responsibilities

• Lead the design and execution of bioinformatics analyses on large-scale human genomic datasets, including whole genome sequencing (WGS) data.
• Perform genomic analyses including variant discovery, genotype-phenotype analysis, population genetics, association studies, rare variant analysis, ancestry-aware analysis, and family-based genomic investigations.
• Analyze and interpret genomic findings within the context of human genetics, population structure, clinical phenotypes, and scientific evidence.
• Assess data quality, analytical assumptions, biases, and limitations to ensure scientific rigor and reproducibility.
• Integrate genomic, clinical, and phenotype data to support translational and clinically relevant research.
• Develop, optimize, and implement bioinformatics workflows, pipelines, and analytical methodologies.
• Evaluate emerging technologies, tools, datasets, and analytical approaches and introduce appropriate innovations to enhance team capabilities.
• Collaborate with bioinformaticians, scientists, clinicians, researchers, and technical teams to deliver cross-functional research objectives.
• Contribute to scientific publications, manuscripts, technical reviews, presentations, and conference activities.
• Communicate analytical methods, results, risks, assumptions, and recommendations effectively to technical and non-technical stakeholders.
• Ensure compliance with organizational policies, regulatory requirements, data governance standards, and scientific best practices.
• Support continuous improvement initiatives that enhance analytical quality, operational efficiency, and scientific outcomes.

Qualifications

• PhD in Bioinformatics, Human Genetics, Genomics, Computational Biology, Biostatistics, Computer Science, or a related discipline.
• Equivalent combination of advanced education and relevant experience may be considered.
• Extensive experience in human genomics, bioinformatics, computational biology, or biomedical data science.
• Proven experience independently leading complex genomic analysis projects.
• Experience working with large-scale genomic datasets and whole genome sequencing data.
• Strong scientific publication record preferred.
• Strong proficiency in Python and/or R.
• Hands-on experience with bioinformatics tools such as PLINK, REGENIE, bcftools, VCFtools, or equivalent platforms.
• Strong understanding of human genetics, population genomics, variant analysis, and genotype-phenotype relationships.
• Experience with clinical, phenotype, or longitudinal healthcare datasets is advantageous.
• Knowledge of OMOP, FHIR, EHR-derived phenotypes, or healthcare data standards is desirable.
• Experience with machine learning, artificial intelligence, or large language model applications in genomics is an advantage.
• Excellent analytical, problem-solving, communication, and stakeholder management skills.
• Demonstrated ability to work independently while contributing effectively within multidisciplinary teams.