Senior Scientist - Medicinal Chemistry

Placements24; Vereeniging; Hybrid; ZAR 1.100.000 - 1.600.000; Vollzeit

Benefits dieser Stelle

Competitive compensation

Medical, dental, and vision insurance

Retirement savings plan

Professional development support

Collaborative R&D environment

Zusammenfassung

Placements24 is seeking a Senior Scientist specializing in Medicinal Chemistry to contribute to drug discovery in Vereeniging, South Africa. The role focuses on design, synthesis, and optimization of novel small molecules, advancing hit-to-lead and lead optimization with biologists and chemists.

You will apply advanced synthetic organic chemistry, SAR analysis, and modern analytical techniques in a collaborative R&D environment aimed at creating life-changing medicines.

Qualifikationen

• Ph.D. in Organic or Medicinal Chemistry is required.
• Minimum of 5 years of medicinal chemistry experience in pharma/biotech.
• Strong synthetic organic chemistry expertise including asymmetric synthesis.
• Proficiency with analytical techniques for compound characterization.
• Experience in SAR exploration and structure-based design.

Aufgaben

• Design and synthesize novel small molecules with desired pharmacological properties.
• Optimize lead compounds to improve potency, selectivity, and PK profiles.
• Develop robust synthetic routes and troubleshoot challenging reactions.
• Characterize compounds using NMR, LC-MS, and HPLC.
• Collaborate with biologists to guide SAR and compound design.
• Maintain detailed records and contribute to scientific reports.

Kenntnisse

Medicinal Chemistry

Asymmetric synthesis

Heterocyclic chemistry

SAR exploration

Analytical techniques

Ausbildung

Ph.D. in Organic Chemistry or Medicinal Chemistry

Jobbeschreibung

About the Role

Our client is seeking a highly skilled Senior Scientist specializing in Medicinal Chemistry to contribute to their drug discovery efforts in Vereeniging. This role focuses on the design, synthesis, and optimization of novel small molecule drug candidates. You will play a critical role in advancing projects through hit-to-lead and lead optimization stages, working closely with biologists and other chemists to achieve challenging therapeutic goals. This position offers a fantastic opportunity to apply advanced synthetic organic chemistry skills in a collaborative and innovative research environment.

Key Responsibilities

• Design and synthesize novel small molecules with desired pharmacological properties.
• Optimize lead compounds to improve potency, selectivity, and pharmacokinetic profiles.
• Develop robust synthetic routes and troubleshoot challenging chemical reactions.
• Characterize synthesized compounds using analytical techniques such as NMR, LC-MS, and HPLC.
• Collaborate effectively with biologists to understand structure-activity relationships (SAR) and guide compound design.
• Maintain detailed records of experiments and contribute to scientific reports and publications.

Requirements

• Ph.D. in Organic Chemistry or Medicinal Chemistry.
• Minimum of 5 years of experience in medicinal chemistry within the pharmaceutical or biotechnology industry.
• Strong expertise in synthetic organic chemistry, including asymmetric synthesis and heterocyclic chemistry.
• Proficiency in modern analytical techniques for compound characterization.
• Experience in structure-based drug design and SAR exploration.
• Excellent problem-solving abilities and a proactive approach to research challenges in Vereeniging.

Benefits

• Competitive salary and bonus structure.
• Comprehensive medical, dental, and vision insurance.
• Retirement savings plan.
• Support for professional development and continuing education.
• A dynamic and collaborative R&D environment focused on creating life-changing medicines.