Senior Medicinal Chemist — Lead Drug Discovery & SAR

Placements24; Vereeniging; Hybrid; ZAR 1.100.000 - 1.900.000; Vollzeit

Benefits dieser Stelle

Annual bonus

Medical, dental, vision coverage

Retirement savings plan

Paid time off

Zusammenfassung

Placements24 in Vereeniging, Gauteng, seeks a Senior Medicinal Chemist to join a pioneering drug discovery team. You will design, synthesize, and optimize novel small molecules with therapeutic potential, collaborating with biologists and computational chemists to advance candidates.

The ideal candidate has a PhD in Organic or Medicinal Chemistry and at least 5 years of hands-on experience in medicinal chemistry within pharma/biotech, with a strong SAR and PK knowledge base.

Qualifikationen

• PhD in Organic Chemistry, Medicinal Chemistry, or closely related field.
• Minimum of 5 years of hands-on medicinal chemistry experience in pharma/biotech.
• Proven track record in designing and synthesizing biologically active small molecules.
• Expertise in modern synthetic organic chemistry techniques and reaction mechanisms.
• Strong understanding of drug discovery, ADME/Tox properties, and SAR analysis.
• Proficiency with analytical characterization (NMR, LC-MS, HPLC).
• Excellent problem-solving, communication, and collaboration skills.

Aufgaben

• Design and synthesize novel small molecules for therapeutic targets identified by R&D.
• Optimize lead compounds for potency, selectivity, PK properties, and safety.
• Collaborate with biologists to interpret SAR studies.
• Utilize computational chemistry to guide design decisions.
• Develop robust synthetic routes and troubleshoot challenges.
• Characterize compounds using NMR, LC-MS, and HPLC.
• Maintain detailed lab notebooks and contribute to patents/publications.
• Stay updated with advancements in medicinal and synthetic chemistry.

Kenntnisse

Medicinal chemistry

Small molecule design

SAR analysis

ADME/Tox knowledge

NMR/LC-MS/HPLC

Computational chemistry

Ausbildung

PhD in Organic or Medicinal Chemistry

Tools

NMR

LC-MS

HPLC

Jobbeschreibung

Placements24 in Vereeniging, Gauteng, seeks a Senior Medicinal Chemist to join a pioneering drug discovery team. You will design, synthesize, and optimize novel small molecules with therapeutic potential, collaborating with biologists and computational chemists to advance candidates.

The ideal candidate has a PhD in Organic or Medicinal Chemistry and at least 5 years of hands-on experience in medicinal chemistry within pharma/biotech, with a strong SAR and PK knowledge base.