Senior Medicinal Chemist – Drug Discovery (Sandton)

Placements24; Sandton; Hybrid; ZAR 1.000.000 - 2.000.000; Vollzeit

Benefits dieser Stelle

Competitive salary

Stock options

Health, dental, and retirement plans

Annual leave and holidays

Professional development

Research environment in Sandton

Zusammenfassung

Placements24 is seeking a Senior Medicinal Chemist to lead design, synthesis, and optimization of novel small molecules in Sandton. You will work within multidisciplinary teams to advance candidates from hit identification to lead optimization.

The ideal candidate has a PhD in Organic or Medicinal Chemistry and at least 5 years in medicinal chemistry, with strong SAR expertise and experience using computational tools.

Qualifikationen

• PhD in Organic Chemistry or Medicinal Chemistry is required.
• Minimum 5 years of post-doctoral or industry experience in medicinal chemistry with focus on small molecules.
• Proven track record in designing and synthesizing NCEs and advancing them in drug discovery.
• Experience with SAR, ADME/Tox concepts, and drug discovery processes.

Aufgaben

• Design and synthesize novel chemical entities (NCEs) with desired properties.
• Develop synthetic routes for target molecules, optimize conditions and yields.
• Conduct SAR studies to guide lead optimization.
• Collaborate with biologists, pharmacologists, and DMPK scientists to integrate data.
• Utilize computational chemistry tools to support drug design.

Kenntnisse

Medicinal chemistry

Synthetic organic chemistry

SAR

Drug design

Computational chemistry

Structure-based drug design

Ausbildung

PhD in Organic Chemistry or Medicinal Chemistry

Tools

Computational chemistry software

Jobbeschreibung

Placements24 is seeking a Senior Medicinal Chemist to lead design, synthesis, and optimization of novel small molecules in Sandton. You will work within multidisciplinary teams to advance candidates from hit identification to lead optimization.

The ideal candidate has a PhD in Organic or Medicinal Chemistry and at least 5 years in medicinal chemistry, with strong SAR expertise and experience using computational tools.