Senior Bioinformatics Scientist (Structural Biology)

Placements24; Upington; Hybrid; ZAR 1.990.000 - 2.985.000; Vollzeit

Benefits dieser Stelle

Competitive salary

Stock options

Health insurance

Zusammenfassung

Placements24 is seeking a Senior Bioinformatics Scientist specializing in structural biology to develop computational methods for analyzing protein structures and protein-ligand interactions in drug discovery, working remotely.

The role requires a PhD and 5+ years in bioinformatics with hands-on experience in Schrödinger Suite, MOE, Rosetta, and GROMACS, plus strong programming in Python and collaborative, cross-disciplinary teamwork.

Qualifikationen

• PhD in Bioinformatics, Computational Biology, Structural Biology, Biophysics, or related field.
• Minimum of 5 years post-doctoral or industry experience in bioinformatics with a strong focus on structural biology.
• Extensive experience with computational structural biology tools and software (e.g., Schrödinger Suite, MOE, Rosetta, GROMACS).
• Proficiency in Python and relevant bioinformatics libraries.
• Strong understanding of protein structure, function, dynamics, and ligand binding.

Aufgaben

• Develop and implement computational pipelines for analysis of protein structures (X-ray, cryo-EM, NMR).
• Utilize computational tools for protein structure prediction and modeling.
• Analyze protein-ligand interactions and binding affinities for drug discovery.
• Develop algorithms for molecular dynamics simulations and conformational analysis.
• Collaborate with structural biologists and chemists to interpret data and guide research directions.
• Develop visualization tools for structural bioinformatics data.
• Analyze data from structural genomics and proteomic studies.
• Write high-quality code and documentation for tools and pipelines.
• Stay current with advancements in structural bioinformatics.

Kenntnisse

Python

Bioinformatics libraries

Data analysis

Remote collaboration

Ausbildung

PhD in Bioinformatics or related

Tools

Schrödinger Suite

MOE

Rosetta

GROMACS

Jobbeschreibung

About the Role

Our client, a pioneering biotechnology company focused on understanding protein structures and functions, is seeking a Senior Bioinformatics Scientist with a specialization in structural biology. This is a fully remote position, allowing talented individuals to contribute from any location. You will be instrumental in developing and applying computational methods to analyze and interpret structural data, predict protein structures, and understand protein-ligand interactions. Your work will directly contribute to drug design and development efforts. This role requires a deep understanding of bioinformatics, computational structural biology, and data analysis. You will collaborate with a multidisciplinary team of computational chemists, structural biologists, and experimental scientists, driving innovation in a **remote** setting.

Key Responsibilities

• - Develop and implement computational pipelines for the analysis of protein structures (e.g., X-ray crystallography, cryo-EM, NMR).


• - Utilize computational tools for protein structure prediction and modeling.


• - Analyze protein-ligand interactions and binding affinities for drug discovery applications.


• - Develop and apply algorithms for molecular dynamics simulations and conformational analysis.


• - Collaborate with structural biologists and chemists to interpret experimental data and guide research directions.


• - Develop visualization tools and methods for structural bioinformatics data.


• - Analyze and interpret data from structural genomics and proteomic studies.


• - Write high-quality code and documentation for computational tools and pipelines.


• - Stay current with the latest advancements in structural bioinformatics and related computational methods.

Requirements

• - PhD in Bioinformatics, Computational Biology, Structural Biology, Biophysics, or a related quantitative field.


• - Minimum of 5 years of post-doctoral or industry experience in bioinformatics with a strong focus on structural biology.


• - Extensive experience with computational structural biology tools and software (e.g., Schrödinger Suite, MOE, Rosetta, GROMACS).


• - Proficiency in programming languages such as Python and experience with relevant bioinformatics libraries.


• - Strong understanding of protein structure, function, dynamics, and ligand binding.


• - Experience with structural data analysis and visualization techniques.


• - Excellent analytical and problem-solving skills.


• - Strong communication and collaboration abilities, essential for **remote** teamwork.


• - Ability to work independently and manage complex computational projects.

Benefits

• - Competitive salary and bonus potential.


• - Comprehensive health, dental, and vision insurance.


• - Stock options and other incentives.


• - Generous budget for professional development, software licenses, and computing resources.


• - Opportunity to contribute to groundbreaking drug discovery projects.


• - Fully **remote** work environment offering significant flexibility.


• - Intellectually stimulating and collaborative research culture.


• - Generous paid time off.