Remote Senior Computational Chemist - Drug Discovery

Placements24; South Africa; Remote; ZAR 1.200.000 - 1.800.000; Vollzeit

Zusammenfassung

Placements24 seeks a Remote Senior Computational Chemist to join its drug discovery team. You will lead computational design, virtual screening, and structure-based optimization, collaborating with medicinal chemists and biologists to accelerate therapeutic candidates.

The role emphasizes standalone work in a fully remote setup, with a focus on advanced modeling, data analysis, and effective communication of complex results to cross-functional teams and publications.

Qualifikationen

• Ph.D. in Computational Chemistry, Cheminformatics, or related field with a strong focus on computational drug discovery.
• Minimum of 6 years of experience in computational chemistry applied to drug discovery.
• Proficiency in computational chemistry software packages (e.g., Schrodinger, MOE, AutoDock, GROMACS).
• Strong programming skills in Python and experience with cheminformatics toolkits (e.g., RDKit, OpenBabel).
• Experience with molecular dynamics simulations and free energy calculations.
• Excellent data analysis and visualization skills.

Aufgaben

• Apply computational chemistry methods to drug discovery projects, including MD and QM.
• Perform virtual screening and docking studies to identify drug candidates.
• Conduct structure-based and ligand-based drug design and pharmacophore modeling.
• Develop cheminformatics tools and databases for library analysis and property prediction.
• Collaborate with medicinal chemists to guide design and synthesis of compounds.
• Analyze large datasets from simulations and assays and communicate findings.

Kenntnisse

Python

Data analysis

Remote work

Ausbildung

Ph.D. in Computational Chemistry, Cheminformatics, or related field

Tools

Schrodinger

MOE

AutoDock

GROMACS

RDKit

OpenBabel

Jobbeschreibung

Remote Senior Computational Chemist - Drug Discovery Modeling

About the Role Our client, a forward-thinking pharmaceutical research organization, is seeking an experienced Senior Computational Chemist to join their drug discovery team. This is a fully remote position, allowing you to contribute to critical research from anywhere. The role involves utilizing advanced computational chemistry techniques, molecular modeling, and cheminformatics to design and optimize novel drug candidates. You will play a key role in virtual screening, hit-to-lead optimization, and structure-based drug design, working closely with medicinal chemists and biologists. This remote opportunity provides a unique chance to leverage your expertise in computational sciences to accelerate the development of new therapies and impact global health, collaborating within a highly skilled virtual team. Key Responsibilities

• Apply computational chemistry methods, including molecular mechanics, dynamics, and quantum mechanics, to drug discovery projects.
• Perform virtual screening and docking studies to identify potential drug candidates.
• Conduct structure-based and ligand-based drug design, including pharmacophore modeling.
• Develop and apply cheminformatics tools and databases for compound library analysis and property prediction.
• Collaborate closely with medicinal chemists to guide the design and synthesis of novel compounds.
• Analyze and interpret large datasets from computational simulations and experimental assays.
• Stay abreast of the latest advancements in computational chemistry, cheminformatics, and drug discovery technologies.
• Effectively communicate computational findings and their implications to cross-functional teams.
• Contribute to scientific publications and presentations.
• Mentor junior computational chemists and contribute to best practices within the team.

Requirements

• Ph.D. in Computational Chemistry, Cheminformatics, or a related field with a strong focus on computational drug discovery.
• Minimum of 6 years of experience in computational chemistry applied to drug discovery.
• Proficiency in computational chemistry software packages (e.g., Schrodinger, MOE, AutoDock, GROMACS).
• Strong programming skills in Python and experience with cheminformatics toolkits (e.g., RDKit, OpenBabel).
• Experience with molecular dynamics simulations and free energy calculations.
• Solid understanding of medicinal chemistry principles and drug discovery processes.
• Excellent data analysis and visualization skills.
• Proven ability to work independently and manage multiple projects in a remote setting.
• Strong written and verbal communication skills, with the ability to present complex technical information clearly.
• A track record of publications in peer-reviewed journals is highly desirable.

Benefits This fully remote position offers a highly competitive salary and bonus structure, performance bonuses, and comprehensive health, dental, and vision insurance. We provide a flexible work schedule, generous paid time off, and a professional development budget for conferences and training. Our client fosters a culture of innovation, scientific rigor, and collaboration, supporting a healthy work-life balance. You will have the opportunity to work with leading researchers in the pharmaceutical industry and contribute to the development of life-changing medicines from the convenience of your home office. Join a dedicated team focused on making a difference in global healthcare.