Remote Principal Research Scientist - Drug Discovery

Placements24; Soweto; Hybrid; ZAR 1,800,000 - 2,600,000; Full time

Benefits offered by this job

Global health insurance

Home office stipend

Retirement savings plan

Flexible working

Remote-first culture

Job summary

Placements24 invites applications for a Principal Research Scientist role in a globally active biopharmaceutical company. This fully remote position leads critical drug discovery initiatives from concept to preclinical candidate, directing molecular biology, pharmacology, and cutting-edge technologies.

You will mentor a high-performing multi-disciplinary team, drive target identification, validation, lead optimization, and strategy development, while ensuring compliance and scientific excellence

Qualifications

• Ph.D. in molecular biology, pharmacology, biochemistry, or related life science.
• At least 10 years in drug discovery research.
• Proven track record leading programs from discovery to preclinical.
• Expertise in assay development, target validation, lead optimization.
• Strong understanding of disease biology and mechanisms of action.
• Experience mentoring scientists and teams.
• Excellent analytical and communication skills.
• Ability to thrive in a fully remote setting.

Responsibilities

• Lead design and execution of complex drug discovery projects, focusing on target identification, validation, and lead optimization.
• Develop and implement innovative experimental strategies and assays to assess compound efficacy and safety.
• Manage and mentor a team of scientists and researchers, providing scientific direction and fostering a collaborative environment.
• Oversee the integration of various discovery disciplines, including medicinal chemistry, biology, and pharmacology.
• Analyze and interpret complex biological and pharmacological data, translating findings into actionable strategies.
• Author high-impact publications and present research findings at international scientific meetings.
• Contribute to the strategic planning and pipeline development of the research organization.
• Ensure compliance with all laboratory safety, ethical, and regulatory guidelines.
• Stay abreast of the latest advancements and emerging technologies in drug discovery and relevant therapeutic areas.

Skills

Drug discovery leadership

Molecular biology

Assay development

Target validation

Lead optimization

Mentoring

Scientific communication

Education

Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or related life sciences

Job description

About the Role

Our client, a globally recognized biopharmaceutical company, is seeking an exceptional Principal Research Scientist to lead critical drug discovery initiatives within their fully remote research division. This senior role is an unparalleled opportunity to drive the identification and development of novel therapeutic agents from concept to preclinical candidate. You will leverage your extensive expertise in molecular biology, pharmacology, and cutting-edge drug discovery technologies to guide research strategies and mentor a high-performing team. Our client fosters a vibrant, collaborative, and remote-first culture, empowering scientists to achieve groundbreaking results. If you possess a proven track record of success in drug discovery and a passion for innovation, we invite you to join us in shaping the future of medicine from anywhere in the world.

Key Responsibilities

• Lead the design and execution of complex drug discovery projects, focusing on target identification, validation, and lead optimization.
• Develop and implement innovative experimental strategies and assays to assess compound efficacy and safety.
• Manage and mentor a team of scientists and researchers, providing scientific direction and fostering a collaborative environment.
• Oversee the integration of various discovery disciplines, including medicinal chemistry, biology, and pharmacology.
• Analyze and interpret complex biological and pharmacological data, translating findings into actionable strategies.
• Author high-impact publications and present research findings at international scientific meetings.
• Contribute to the strategic planning and pipeline development of the research organization.
• Ensure compliance with all laboratory safety, ethical, and regulatory guidelines.
• Stay abreast of the latest advancements and emerging technologies in drug discovery and relevant therapeutic areas.

Requirements

• Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or a related life science discipline.
• Minimum of 10 years of progressive experience in drug discovery research within the pharmaceutical or biotechnology industry.
• Demonstrated success in leading multiple drug discovery programs from early discovery through to preclinical development.
• Expertise in assay development, target validation, and lead optimization methodologies.
• Strong understanding of disease biology and mechanisms of action for therapeutic intervention.
• Proven ability to manage and mentor scientific teams effectively.
• Excellent analytical, problem-solving, and critical thinking skills.
• Exceptional written and verbal communication skills, with a strong publication record.
• Ability to thrive and lead effectively in a fully remote work environment.

Benefits

Our client offers a highly competitive salary package, with earnings potentially reaching R per annum, commensurate with experience and contribution. The comprehensive benefits package includes a generous home office stipend, global health insurance, a significant retirement savings contribution, and flexible working arrangements. We are dedicated to the professional growth of our remote workforce, providing access to extensive online learning resources, virtual conferences, and opportunities for career advancement. This fully remote role allows you to make a profound impact on human health while enjoying exceptional work-life balance and flexibility.