Protein Analytics Scientist (Protein Science I)

Modex; Cape Town; On-site; ZAR 600,000 - 800,000; Full time

Job summary

A leading biopharmaceutical company in Cape Town is seeking a highly skilled analytical scientist to join their Protein Science team. This role involves characterizing novel therapeutic antibodies using advanced analytical techniques. The successful candidate will collaborate within a multidisciplinary team to drive the development of innovative biotherapeutics, ensuring accurate documentation and contributing to research projects in a fast-paced environment.

Qualifications

• PhD in relevant life science disciplines required.
• Strong experience in advanced chromatography and mass spectroscopy techniques.

Responsibilities

• Collaborate with diverse scientific backgrounds in biologics research.
• Develop and optimize analytics methods for biotherapeutic candidates.
• Conduct detailed biochemical/biophysical characterization of therapeutic molecules.

Skills

Analytical Skills

Communication

Problem-Solving

Education

PhD in Analytical Chemistry

PhD in Biochemistry

PhD in Pharmaceutical Science

Tools

HPLC

UPLC

Q-TOF

LC-MS/MS

Orbitrap

Biopharma Finder

FPLC

aSEC

aHIC

RP-HPLC

Job description

Company Overview

ModeX Therapeutics, an OPKO Health subsidiary, is a clinical-stage biopharmaceutical company developing next-generation multispecific antibodies and vaccines for cancer and infectious disease. ModeX's modular antibody platforms unite the power of multiple biologic components in a single molecule to create multispecific antibodies with greater versatility and potency to fight complex diseases more effectively than traditional approaches. Our current pipeline includes immuno-oncology candidates against both solid and hematological tumors as well as medicines and vaccines for several of the world's most pressing viral threats. Our founding team includes globally recognized medical innovators with proven track records of delivering breakthroughs for patients.

External Description

Position Summary:

We are seeking a highly skilled and motivated analytical scientist to join our Protein Science team. The individual will be part of an established multidisciplinary biologics drug discovery and development team to characterize novel therapeutic antibodies using state-of-the-art analytical instruments. This is an exciting opportunity to be part of a cross-functional team and contribute to the development of cutting-edge biotherapeutics in a fast-paced, rapidly growing biotech company with a bold vision.

Major responsibilities

• Effectively collaborate with colleagues with diverse scientific background and contribute to our interdisciplinary biologics research teams to drive the screening, characterization and optimization of innovative therapeutic molecules.
• Develop and optimize analytics methods for both routine QC and detailed MAM (multiple-attribute method) analysis of biotherapeutic candidates using advanced LC-MS techniques including intact mass, peptide mapping, post-translational modification (PTMs) profiling.
• Serve as a key member of the protein analytics core team to conduct detailed biochemical/biophysical characterization and developability assessment of therapeutic molecules.
• Be responsible for experimental planning, execution, data analysis/interpretation, and communication with cross-functional teams for the advancement and successful completion of research projects.
• Stay scientifically current and contribute to the implementation of innovative technology and instrumentation to improve ModeX’s biologics drug discovery workflows and biologics characterization capabilities.
• Ensure accurate and timely documentation of experimental design, methods and results in electronic laboratory notebooks, and support regulatory submissions with data and interpretations.

Qualifications

• PhD in analytical chemistry, biochemistry, pharmaceutical science or other relevant life science disciplines.
• Strong experience in advanced liquid chromatography and mass spectroscopy techniques and platforms including HPLC, UPLC, Q-TOF and LC-MS/MS for the characterization of biotherapeutics. Direct experience in high-resolution LC MS systems such as Orbitrap and Biopharma Finder is desired.
• Familiar with routine protein analytics technologies for biologics production and characterization including FPLC, aSEC, aHIC, and RP-HPLC.
• Knowledge in antibody structure and function, and experience in antibody drug discovery and multispecific antibody development are preferred.
• Track record of scientific accomplishments as evidenced by a strong publication record and a drive for self-development with a focus on scientific know-how.
• Excellent written and oral communication, organization, and data analysis skills. Outstanding troubleshooting and problem-solving skills.
• Highly adaptable to a fast-paced work environment and capable of working both independently and collaboratively within project teams.

ModeX Therapeutics is an Equal Opportunity Employer