Principal Scientist - Drug Discovery

Placements24; Centurion; On-site; ZAR 1,500,000 - 2,100,000; Full time

Job summary

Placements24's client, a pioneering pharmaceutical research firm in Centurion, Gauteng, is seeking a distinguished Principal Scientist to lead critical drug discovery initiatives. The role requires guiding design, synthesis, and preclinical evaluation of novel small molecules, setting scientific direction, and managing project teams across discovery stages.

The successful candidate will drive SAR analyses, optimize pharmacology, DMPK, and toxicology considerations, collaborate with external

Qualifications

• PhD required in Medicinal Chemistry, Organic Chemistry, Pharmacology, or related field.
• At least 10 years of progressive experience in drug discovery.
• Proven track record leading discovery projects from inception to preclinical candidate selection.
• Expertise in modern medicinal chemistry techniques, SAR analysis, and drug design principles.
• Strong pharmacology, DMPK, and toxicology knowledge.
• Excellent leadership, communication, and interpersonal skills.
• Experience with biologics discovery is a plus.
• Must be legally authorized to work in South Africa.

Responsibilities

• Lead and manage multidisciplinary drug discovery project teams, from target identification through to candidate nomination.
• Design and oversee the synthesis and optimization of novel small molecules with desired pharmacological profiles.
• Develop and implement in vitro and in vivo assays to assess compound efficacy, selectivity, and pharmacokinetic properties.
• Critically evaluate experimental data, identify potential risks and mitigation strategies, and make informed go/no-go decisions.
• Collaborate closely with external partners, key opinion leaders, and internal stakeholders.
• Author and contribute to scientific publications, patent applications, and regulatory submissions.
• Provide scientific mentorship and guidance to junior researchers and scientists.
• Stay abreast of the latest advancements in medicinal chemistry, pharmacology, and relevant therapeutic areas.
• Contribute to strategic planning and business development activities for the R&D division.

Skills

Leadership

Drug discovery leadership

Medicinal chemistry

SAR analysis

Project management

Education

PhD in Medicinal Chemistry/Organic Chemistry/Pharmacology

Job description

About the Role

Our client, a pioneering pharmaceutical research firm, is actively seeking a distinguished Principal Scientist to lead critical drug discovery initiatives within their state-of-the-art laboratories in Centurion, Gauteng. This senior role requires a deep understanding of medicinal chemistry, pharmacology, and early-stage drug development. The successful candidate will guide the design, synthesis, and preclinical evaluation of novel small molecule therapeutics. You will be responsible for setting scientific direction, managing project teams, and ensuring the efficient progression of drug candidates through the discovery pipeline. This is a highly visible position offering the opportunity to shape the company's therapeutic pipeline and contribute significantly to addressing unmet medical needs. The role is based in our expansive Centurion, Gauteng research campus, providing access to world-class facilities and a collaborative environment. We are looking for an experienced leader with a proven track record in successful drug discovery programs.

Key Responsibilities

• Lead and manage multidisciplinary drug discovery project teams, from target identification through to candidate nomination.
• Design and oversee the synthesis and optimization of novel small molecules with desired pharmacological profiles.
• Develop and implement in vitro and in vivo assays to assess compound efficacy, selectivity, and pharmacokinetic properties.
• Critically evaluate experimental data, identify potential risks and mitigation strategies, and make informed go/no-go decisions.
• Collaborate closely with external partners, key opinion leaders, and internal stakeholders.
• Author and contribute to scientific publications, patent applications, and regulatory submissions.
• Provide scientific mentorship and guidance to junior researchers and scientists.
• Stay abreast of the latest advancements in medicinal chemistry, pharmacology, and relevant therapeutic areas.
• Contribute to strategic planning and business development activities for the R&D division.

Requirements

• Ph.D. in Medicinal Chemistry, Organic Chemistry, Pharmacology, or a related discipline.
• A minimum of 10 years of progressive experience in drug discovery within the pharmaceutical or biotechnology industry.
• Demonstrated success in leading drug discovery projects from inception to preclinical candidate selection.
• Expertise in modern medicinal chemistry techniques, structure-activity relationship (SAR) analysis, and drug design principles.
• Strong understanding of pharmacology, DMPK, and toxicology principles.
• Proven ability to manage complex projects, timelines, and budgets effectively.
• Excellent leadership, communication, and interpersonal skills.
• Experience with biologics discovery is a plus.
• Must be legally authorized to work in South Africa.

Benefits

Our client offers a highly competitive salary, a comprehensive benefits package including medical, dental, and retirement plans, and potential for significant performance-based bonuses. Employees enjoy access to cutting-edge research facilities in Centurion, Gauteng , opportunities for career advancement and professional development, and a stimulating work environment focused on innovation and scientific excellence. Relocation assistance may be available for highly qualified candidates. Join a team dedicated to making a real difference in patient lives.