Lead Research Scientist - Pharmaceutical Discovery

Placements24; South Africa; Hybrid; ZAR 1,800,000 - 2,500,000; Full time

Benefits offered by this job

Competitive base salary

Performance-based bonuses

Stock options

Health, dental and vision insurance

Retirement plan

Paid time off

Professional development

Cutting-edge research facilities

Job summary

Placements24 in Gauteng seeks a Lead Research Scientist to drive drug discovery programs, identify novel targets, and guide preclinical strategy. Based in Tembisa, this hybrid role blends hands-on lab work with strategic leadership.

You will lead SAR and medicinal chemistry efforts, develop assays, mentor junior scientists, collaborate with pharmacologists and toxicologists, and contribute to patents and publications.

Qualifications

• PhD required in chemistry, pharmacology, biochemistry, or related life science discipline.
• Minimum 7 years in pharmaceutical R&D with leadership in drug discovery.
• Proven track record in advancing compounds to preclinical development.

Responsibilities

• Lead drug discovery projects from target identification through lead optimization.
• Develop and implement novel assay methodologies to assess compound efficacy and MOA.
• Oversee synthesis and characterization of small molecule candidates.
• Analyze complex data to guide project direction.
• Collaborate with pharmacologists, toxicologists, and clinical teams.
• Manage external collaborations with academia and CROs.
• Mentor junior scientists and foster innovation.
• Prepare research reports, presentations, and support patents/publications.
• Ensure compliance with safety and regulatory guidelines.

Skills

Leadership

Project management

Drug discovery

Medicinal chemistry

SAR analysis

Assay development

Biochemical assays

Cell-based assays

Scientific literature review

Communication

Education

PhD in Chemistry, Pharmacology, Biochemistry, or related life science

Tools

Assay development platforms

Analytical instrumentation

Job description

About the Role

Our client is a pioneering force in pharmaceutical innovation, seeking an exceptional Lead Research Scientist to drive critical drug discovery initiatives. Based in **Tembisa, Gauteng, ZA**, this role offers a compelling blend of laboratory-based research and strategic leadership. You will spearhead projects focused on identifying and validating novel therapeutic targets, working collaboratively with cross-functional teams. The ideal candidate possesses a deep understanding of disease biology and a proven track record in medicinal chemistry or pharmacology. This hybrid role allows for flexible work arrangements, balancing focused work at home with essential in-person collaboration in our state-of-the-art facilities. Your expertise will be pivotal in shaping the future pipeline of life-saving medicines. We encourage applications from seasoned professionals eager to make a significant impact in a rapidly evolving scientific landscape.

Key Responsibilities

• Lead the design and execution of drug discovery projects from target identification through lead optimization.
• Develop and implement novel assay methodologies to assess compound efficacy and mechanism of action.
• Oversee the synthesis and characterization of small molecule drug candidates.
• Analyze and interpret complex experimental data, drawing insightful conclusions to guide project direction.
• Collaborate closely with pharmacologists, toxicologists, and clinical development teams.
• Manage external collaborations with academic institutions and contract research organizations.
• Mentor and supervise junior scientists, fostering a culture of scientific excellence and innovation.
• Prepare research reports, presentations, and contribute to patent filings and publications.
• Ensure compliance with all relevant safety and regulatory guidelines.

Requirements

• PhD in Chemistry, Pharmacology, Biochemistry, or a related life science discipline.
• Minimum of 7 years of relevant industry experience in pharmaceutical research and development.
• Demonstrated success in leading drug discovery programs and advancing compounds into preclinical development.
• Expertise in medicinal chemistry principles, structure-activity relationship (SAR) analysis, and synthetic organic chemistry.
• Proficiency in assay development and validation, including biochemical and cell-based assays.
• Strong understanding of molecular biology and disease mechanisms relevant to therapeutic areas of interest.
• Excellent leadership, project management, and communication skills.
• Experience working in a hybrid work environment, effectively balancing remote and on-site responsibilities.
• Ability to critically evaluate scientific literature and translate findings into actionable research plans.
• Record of publications and/or patents in peer-reviewed journals.

Benefits

• Our client provides a highly competitive compensation package, including a substantial base salary, performance-based bonuses, and stock options.
• Employees benefit from comprehensive health, dental, and vision insurance, a generous retirement savings plan, and an extensive paid time off policy.
• We support professional development through ongoing training, conference attendance, and opportunities for advancement.
• Our client offers access to cutting-edge research facilities and a collaborative work environment.
• Wellness programs and employee assistance services are also available to support your overall well-being.
• This role is ideal for a scientific leader seeking to make a tangible impact on global health.