Principal Research Scientist - Neuroscience Drug Development

Placements24; Upington; Hybrid; ZAR 1,800,000 - 3,000,000; Full time

Benefits offered by this job

Health insurance

Dental and vision coverage

Generous leave and holidays

Career development and leadership培训

Job summary

Placements24 is seeking a Principal Research Scientist in Upington, Northern Cape, to lead neuroscience drug discovery and preclinical development. You will steer cross-functional teams, design in vitro and in vivo studies, and shape the strategic pipeline for novel therapeutics addressing CNS disorders.

The role demands a PhD and 8–10 years in neuroscience drug discovery, with a track record in advancing programs toward clinical development and strong publication credentials.

Qualifications

• Ph.D. in Neuroscience, Pharmacology, Biology, or related discipline.
• 8–10 years in neuroscience drug discovery and development, preferably in pharma.
• Experience with preclinical models of neurological/psychiatric diseases.
• Strong understanding of CNS molecular/cellular mechanisms.
• Proven leadership of multidisciplinary research teams and projects.
• Excellent communication and publication track record; IND experience desirable.

Responsibilities

• Lead preclinical neuroscience drug development programs from validation to candidate selection.
• Oversee in vitro and in vivo studies to assess efficacy and safety of candidates.
• Identify and validate novel targets for neurological/psychiatric diseases.
• Collaborate with chemists, pharmacologists, toxicologists, and specialists to progress programs.
• Provide scientific leadership and mentorship to research teams.
• Develop strategies for preclinical development including biomarkers and assays.
• Contribute to regulatory documents and scientific publications.

Skills

Leadership

Project management

Analytical thinking

Scientific communication

Education

Ph.D. in Neuroscience/Pharmacology/Biology

Job description

About the Role

Our client, a leading biopharmaceutical company committed to addressing unmet medical needs, is seeking an accomplished Principal Research Scientist specializing in Neuroscience Drug Development for their research hub in Upington, Northern Cape . This senior position will drive the discovery and development of novel therapeutics for a range of neurological and psychiatric disorders. You will lead cross-functional research teams, design and execute innovative preclinical studies, and contribute to the strategic pipeline planning. The ideal candidate will possess a profound understanding of neurobiology, CNS drug discovery, and a proven track record of successfully advancing programs from discovery into clinical development. This is an exceptional opportunity to shape the future of neuroscience research within a dynamic and scientifically driven organization. We foster a culture of collaboration, innovation, and scientific excellence. The successful applicant will play a critical role in bringing transformative treatments to patients suffering from debilitating brain disorders. This role demands a strong scientific vision and a commitment to impactful research.

Key Responsibilities

• Lead and manage preclinical neuroscience drug development programs, from target validation through to candidate selection.
• Design, oversee, and interpret complex in vitro and in vivo studies to assess the efficacy and safety of novel drug candidates.
• Identify and validate novel therapeutic targets for neurological and psychiatric diseases.
• Collaborate closely with medicinal chemists, pharmacologists, toxicologists, and other specialists to ensure seamless progression of programs.
• Provide scientific leadership and mentorship to a team of research scientists and associates.
• Develop and implement strategies for preclinical development, including biomarker identification and assay development.
• Contribute to the preparation of regulatory documents (e.g., IND filings) and scientific publications.
• Present research findings and strategic recommendations to senior management and key stakeholders.
• Stay abreast of the latest scientific advancements and competitive landscape in neuroscience drug development.
• Foster a collaborative and innovative research environment within the team.

Requirements

• Ph.D. in Neuroscience, Pharmacology, Biology, or a related discipline.
• A minimum of 8-10 years of progressive experience in neuroscience drug discovery and development, preferably within the pharmaceutical industry.
• Demonstrated expertise in preclinical models of neurological and psychiatric diseases.
• Strong understanding of molecular and cellular mechanisms underlying CNS disorders.
• Proven experience in leading multidisciplinary research teams and managing projects effectively.
• Excellent analytical, problem-solving, and strategic thinking skills.
• Exceptional written and verbal communication skills, with a strong publication and presentation record.
• Experience with regulatory affairs and IND-enabling studies is highly desirable.
• A passion for developing novel therapies for challenging neurological conditions.

Benefits

• An annual salary ranging from R to R , commensurate with experience and leadership impact.
• Comprehensive health, dental, and vision insurance plans.
• Generous annual leave and paid holidays.
• Significant opportunities for career advancement and professional development, including leadership training.
• Access to state-of-the-art research facilities and advanced scientific technologies.
• Performance-based bonuses and potential for equity participation.
• A stimulating and highly collaborative research environment.
• Retirement savings plan with a generous employer match.