Principal Research Scientist - Immunology

Placements24; Stellenbosch; Hybrid; ZAR 1,500,000 - 2,500,000; Full time

Benefits offered by this job

Salary + equity

Medical insurance

Dental insurance

Vision insurance

Performance-based bonuses

Job summary

Placements24 in Stellenbosch, Western Cape, seeks a Principal Research Scientist - Immunology to lead key research programs and advance discovery and preclinical development of novel immunotherapies.

The role requires a PhD in Immunology with 8–10 years of leadership or principal scientist experience, deep expertise in adaptive and innate immunology, and a track record of scientific innovation and impactful publications.

Qualifications

• PhD in Immunology or related life science field.
• 8–10 years post-doctoral/industry experience with leadership roles.
• Proven track record in immunology research and publications.

Responsibilities

• Lead discovery and preclinical immunology programs.
• Design and interpret immunological assays and models.
• Mentor scientists and manage external collaborations.
• Present findings to leadership and at conferences.
• Contribute to patent filings and publications.
• Collaborate with cross-functional teams across biotech.
• Ensure scientific integrity and ethical standards.
• Stay updated on immunology and immuno-oncology advances.

Skills

Leadership

Immunology expertise

Flow cytometry

ELISpot

Data analysis

Education

PhD in Immunology

Tools

Flow cytometry

ELISpot

Cell culture

Job description

About the Role

Our client, a cutting-edge biotechnology company at the forefront of discovering novel immunotherapies, is seeking a highly experienced and visionary Principal Research Scientist - Immunology to lead key research programs in Stellenbosch, Western Cape . This senior role is pivotal in driving the discovery and preclinical development of innovative treatments for autoimmune diseases and cancer. You will leverage your deep expertise in immunology, cell biology, and drug discovery to design and execute complex experiments, interpret data, and guide project strategy. The ideal candidate is a recognized leader in the field with a proven track record of scientific innovation and impactful publications. This is an unparalleled opportunity to shape the future of immunology research and contribute to the development of life-changing therapies within a dynamic and collaborative R&D environment.

Key Responsibilities

• Lead and direct research projects focused on understanding disease mechanisms and identifying novel therapeutic targets in immunology.
• Design, implement, and interpret complex immunological assays, including flow cytometry, ELISpot, cell proliferation assays, and cytokine analysis.
• Develop and validate innovative in vitro and ex vivo models for assessing therapeutic efficacy and MoA.
• Mentor and guide a team of research associates and scientists, fostering a culture of scientific excellence and innovation.
• Collaborate closely with cross-functional teams, including antibody engineering, DMPK, and translational medicine.
• Prepare and present research findings to internal leadership, scientific advisory boards, and at international conferences.
• Contribute significantly to patent filings and peer-reviewed publications.
• Manage external collaborations with academic institutions and key opinion leaders.
• Ensure all research activities are conducted with the highest scientific integrity and ethical standards.
• Stay abreast of the latest advancements and emerging technologies in immunology and immuno-oncology.

Requirements

• Ph.D. in Immunology, Molecular Biology, Cell Biology, or a related life science discipline.
• A minimum of 8-10 years of post-doctoral and/or industry experience in immunology research, with a significant portion in a leadership or principal scientist role.
• Extensive expertise in adaptive and innate immunology, with a strong understanding of immune cell function and signaling pathways.
• Proven track record of successfully leading research programs from discovery through to preclinical development.
• Demonstrated ability to develop and validate complex immunological assays and cellular models.
• Exceptional problem-solving, critical thinking, and analytical skills.
• Outstanding written and verbal communication skills, with a strong publication record.
• Experience in mentoring and managing scientific staff.
• Familiarity with various therapeutic modalities (e.g., antibodies, small molecules) is desirable.
• Ability to thrive in a fast-paced, innovative, and collaborative biotech environment.

Benefits

• Our client offers a highly competitive salary and equity package, along with a comprehensive benefits program including medical, dental, vision insurance, a generous 401(k) plan, and performance-based bonuses.
• We are dedicated to fostering professional growth through continuous learning, conference participation, and opportunities for leadership.
• The work environment in Stellenbosch, Western Cape is dynamic, intellectually stimulating, and highly collaborative.
• Employees are encouraged to drive innovation and contribute to the company's scientific mission.
• Career advancement pathways are well-defined for high-performing individuals.
• We are an equal opportunity employer committed to diversity.