Lead Research Scientist - Pharmaceutical Development

Placements24; Sandton; On-site; ZAR 1,500,000 - 2,400,000; Full time

Benefits offered by this job

Competitive salary

Health/Dental/Vision insurance

Professional development

Advanced lab facilities

Collaborative environment

Job summary

Placements24 in Sandton seeks a dynamic Lead Research Scientist to head pharmaceutical development, guiding formulation, characterization and stability studies. You will lead scientists, coordinate with cross-functional teams, and steer programs from discovery to stages close to IND submission.

The role requires a Ph.D. and 10+ years in pharma R&D, with at least 3 years in leadership. Outstanding collaboration and regulatory acumen are essential in this fast-paced setting in Sandton.

Qualifications

• Ph.D. in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related field.
• Minimum 10 years of pharmaceutical R&D experience with at least 3 years in a leadership role.
• Extensive knowledge of formulation science, drug delivery systems, and analytical techniques for characterization.
• Proven experience leading drug development projects from early stage to IND submission.
• Strong regulatory knowledge for drug development.
• Excellent leadership and cross-functional collaboration skills in Sandton.

Responsibilities

• Lead formulation development and optimization of small molecule and biologic candidates.
• Design and execute stability studies per ICH guidelines.
• Develop/validate analytical methods for drug products and impurities.
• Oversee pre-clinical formulation and drug delivery studies.
• Mentor and manage a team of formulation scientists; guide career development.
• Collaborate with medicinal chemistry, DMPK, and clinical teams to ensure project progression.

Skills

Formulation science

Drug delivery systems

Analytical techniques

Leadership

Cross-functional collaboration

Education

Ph.D. in Pharmaceutical Sciences/ Chemistry/ Chemical Engineering

Job description

About the Role

Our client is seeking a dynamic and experienced Lead Research Scientist to head their pharmaceutical development initiatives in Sandton . This critical role involves guiding the formulation, characterization, and stability studies of new drug candidates, ensuring their readiness for clinical trials. You will lead a team of scientists, collaborate with cross‑functional departments, and contribute to the strategic direction of drug development programs. This is a premier opportunity to influence the advancement of novel therapeutics within a leading pharmaceutical research organization, driving innovation from discovery through to commercialization.

Key Responsibilities

• Lead the formulation development and optimization of small molecule and biologic drug candidates.
• Design and execute comprehensive stability studies according to ICH guidelines.
• Develop and validate analytical methods for characterizing drug products and their impurities.
• Oversee pre‑clinical formulation and drug delivery studies.
• Mentor and manage a team of formulation scientists, providing technical guidance and career development support.
• Collaborate closely with medicinal chemistry, DMPK, and clinical teams to ensure seamless project progression.

Requirements

• Ph.D. in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related field.
• A minimum of 10 years of experience in pharmaceutical research and development, with at least 3 years in a leadership role.
• Extensive knowledge of formulation science, drug delivery systems, and analytical techniques for pharmaceutical characterization.
• Proven experience in leading drug development projects from early stage to IND submission.
• Strong understanding of regulatory requirements for drug development.
• Excellent leadership, communication, and interpersonal skills for effective team management and cross‑functional collaboration in Sandton .

Benefits

• An industry‑leading annual salary and comprehensive bonus structure.
• Exceptional health, dental, and vision insurance coverage.
• Significant investment in professional development, including external training and conferences.
• Access to advanced laboratory facilities and cutting‑edge pharmaceutical development technologies.
• A vibrant and collaborative research environment committed to advancing healthcare.