VP, Liver Development Asset Leader

primemedicine; Cambridge (MA); Hybrid; USD 250,000 - 420,000; Full time

Job summary

Prime Medicine is seeking an experienced Development Asset Leader to oversee in vivo liver programs from IND clearance through regulatory approval, initially focusing on Wilson's Disease and Alpha-1 Antitrypsin Deficiency. The role requires strategic and operational leadership of a cross-functional team in a fast-paced biotech setting.

The ideal candidate will manage integrated development plans, interact with regulators and CRO/CDMO partners, and scale the liver portfolio into a franchise with

Qualifications

• Advanced degree in life sciences, medicine, or related field (PhD, MD, PharmD) preferred; equivalent industry experience considered

Responsibilities

• Own the Integrated Development Plan for liver assets from IND acceptance through regulatory approval/licensure, including trial design input, data package strategy, and key go/no-go decision points
• Anticipate, frame, and escalate the critical considerations that materially change the asset's risk/value profile to executive management
• Lead a matrixed team spanning Clinical, Regulatory, CMC/Manufacturing, Biostatistics, Pharmacovigilance, Med Affairs/Patient Advocacy, and Commercial
• Deploy, where appropriate, AI-enabled project management tooling (timelines, risk registers, cross-functional dashboarding)
• As the liver franchise expands, help design the team structure, governance cadence, and knowledge-transfer processes to advance Prime's portfolio
• Serve as a key point of contact with CROs/CDMOs, KOLs, and patient advocacy groups for the asset, and represent the asset in regulatory interactions alongside Regulatory Affairs

Education

Advanced degree in life sciences, medicine, or related field

Job description

Prime Medicine is seeking an experienced Development Asset Leader to oversee in vivo liver programs from IND clearance through regulatory approval, initially focusing on Wilson's Disease and Alpha-1 Antitrypsin Deficiency. The role requires strategic and operational leadership of a cross-functional team in a fast-paced biotech setting.

The ideal candidate will manage integrated development plans, interact with regulators and CRO/CDMO partners, and scale the liver portfolio into a franchise with