VP, Disease Business Unit General Manager, US

MFS Investments; Boston (MA); Sur place; USD 368 000 - 552 000; Plein temps

Avantages offerts par ce poste

On-site designated

Annual bonus eligibility

Equity awards

Résumé du poste

Vertex seeks a seasoned commercial executive to serve as VP U.S. General Manager, accountable for end-to-end U.S. business performance, including results delivery, performance management, budget, and strategic priorities for the portfolio.

The VP GM will lead a fully integrated U.S. Business Unit with accountability for commercial execution across Sales and Marketing, and cross-functional alignment with Market Access, Patient Services, Analytics, Medical Affairs, R&D, Manufacturing, and

Qualifications

• 15+ years of pharmaceutical/biotech leadership experience.
• Experience leading large matrixed organizations.
• Proven ability to drive revenue, profitability, and long-range plans.

Responsabilités

• Owns full P&L for the U.S. designated Business Unit.
• Leads cross-functional commercial teams across Sales and Marketing.
• Drives governance across Market Access, Patient Services, Analytics, and other functions.
• Ensures launch execution and lifecycle management for future indications.
• Maintains leadership bench with strong succession planning.
• Oversees U.S. revenue forecast, expenses, and resource allocation.

Connaissances

P&L management

Commercial leadership

Cross-functional leadership

Strategic planning

Executive communication

Budget management

Description du poste

VP U.S. General Manager (GM)

Vertex is seeking a seasoned commercial executive to serve as VP U.S. General Manager (GM), accountable for end-to-end business performance, including results delivery, performance management, budget and strategic priorities for their designated portfolio, in the US. The VP GM will lead a fully integrated U.S. Business Unit, with responsibility for commercial execution through cross-functional alignment to sustain market leadership while preparing for future innovation.

Key Duties & Responsibilities

• Owns full P&L responsibility for the U.S. designated Business Unit, delivering against revenue, profitability, and long‑range plan commitments
• Leads an established commercial organization with opportunities for future builds with direct reports across Sales and Marketing
• Drives cross‑functional leadership and decision‑making across Market Access, Patient Services, Analytics, Commercial Operations, Medical Affairs, R&D, Manufacturing, Legal, Regulatory, Government Affairs, and Patient Advocacy
• Ensures continued excellence in launch execution for future indication expansions, and lifecycle management
• Develops and maintains a high‑performing leadership bench with strong succession planning
• Serves as enterprise steward of Vertex’s designated therapeutic area franchise in the U.S., balancing near‑term performance with long‑term sustainability
• Leads the organization through the dynamics of a highly penetrated, mature market
• Partners with Medical Affairs and Patient Services to ensure patient‑centric engagement models reflecting lifelong treatment journeys
• Maintains trusted relationships with the Disease communities including advocacy organizations and treatment centers
• Owns the U.S. revenue forecast, expense management, and resource allocation, in collaboration with the Business Unit Leadership
• Champions a culture of operational rigor, continuous improvement, and ethical leadership, ensuring full compliance with all company policies and regulatory standards

Required Experience

Typically requires 15+ years of pharmaceutical or biotech experience, with deep commercial leadership exposure

Minimum of 8–10 years of senior people leadership experience, including responsibility for large, matrixed organizations

Demonstrated success leading large, in‑market franchises with sustained performance over time

Preferred experience includes:

• Portfolio and lifecycle management
• Operating effectively within highly visible, enterprise‑critical franchises
• Experience engaging externally with advocacy groups, policymakers, and senior healthcare stakeholders

Required Knowledge / Skills

• Proven enterprise‑level commercial leadership with strong strategic, financial, and operational acumen
• Ability to lead through scale and complexity, balancing performance delivery with long‑term franchise stewardship
• Exceptional executive communication skills, with the ability to influence the EC, Board, and external stakeholder levels
• Strong track record of building leaders, not just teams, and developing future general managers
• Deep experience operating in cross‑functional, highly regulated environments
• Demonstrated ability to manage significant budgets and complex trade‑offs
• Uncompromising commitment to ethics, compliance, and Vertex’s values and reputation

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision‑making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range

$368,000 - $552,000

Disclosure Statement

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job‑related factors permitted by law.

Flex Designation

On‑Site Designated

Flex Eligibility Status

In this On‑Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]