VP Clinical Development & Global Program Lead, Lung Cancer

Erasca, Inc.; Northern, San Diego (KY, CA); Hybrid; USD 390,000 - 435,000; Full time

Benefits offered by this job

Paid time off

Medical, dental and vision plans

Disability coverage

Life/AD&D

FSAs/HSA

Pet insurance

401(k) with Erasca contribution

Employee stock purchase program

Job summary

Erasca, Inc. is seeking a visionary VP, Clinical Development and Global Program Lead for Lung Cancer to guide strategy, lead studies, and collaborate with senior leadership across the Erasca portfolio.

You will oversee trial design, data interpretation, and regulatory interactions, while mentoring a team of medical directors and clinical scientists. The role is based in the United States with a competitive benefits package.

Qualifications

• MD degree or equivalent, with subspecialty fellowship training and board certification or eligibility in Oncology or Oncology/Hematology.
• 8-10+ years of oncology clinical trial and drug development experience in pharma/biotech.
• Experience as the clinical lead on late-stage lung cancer programs.
• Experience leading or being closely involved in regulatory filings and health authority interactions.
• Exposure to early development and the transition from FIH to registrational trials preferred.
• Extensive knowledge of clinical trial methodology and regulatory/compliance requirements.
• Demonstrated ability to collaborate in a matrixed team environment.
• Executive leadership to educate and influence stakeholders and drive strategic decisions.
• Strong interpersonal and writing skills with the ability to tailor communication to diverse audiences.
• Commitment to science and patients.

Responsibilities

• Provide medical direction and high-quality scientific guidance to shape strategy and execution of the lung cancer program.
• Lead the clinical development subteam for all lung cancer studies.
• Design and implement novel and efficient clinical trials to assess appropriate endpoints.
• Oversee safety and efficacy data review and interpretation across studies.
• Lead regulatory strategy and contribute to INDs, NDAs and other filings.
• Serve as Medical lead on clinical programs and represent Clinical Development.
• Mentor and grow a high-performing team of medical directors and clinical scientists.
• Foster relationships with R&D partners and stakeholders across Erasca.
• Present data at scientific, medical, and regulatory meetings.

Skills

Executive leadership

Cross-functional collaboration

Medical writing

Strategic thinking

Communication skills

Education

MD degree

Oncology fellowship

Job description

Erascais a clinical-stage precision oncology company focused on discovering, developing and commercializing medicines for the benefit of patients with cancer. Our programs take novel approaches to shutting down one of cancer’s most commonly mutated signaling cascades, the RAS/MAPK pathway, which affects approximately 5.5 million lives each year worldwide. The name “Erasca” has an important embedded meaning: it is a contraction of our audacious hope to “erase cancer” that drives our mission and everything that we do on behalf of patients with cancer.

Reporting to the ChiefMedicalOfficer, theVPClinical Developmentand Global ProgramLead (GPL)for Lung Cancer willprovide medical leadership and oversight ofthelung cancerdevelopmentprogramand collaborate with the CMOacross theErascaportfolio. Responsibilities will include clinical development strategy,protocol development, registrationalstrategyand execution, KOL and academic site interactions, competitive landscape diligence, presentation of data, andother clinical deliverables.In addition, the VP will be ahands–on drug developer andwillserve as clinical lead and/or medical monitor onindividualstudies.

Essential Duties and Responsibilities:

• Providemedical direction and high-quality scientific and clinical knowledge to guide the strategy and execution ofthelung cancerprogramandcontribute to clinical decision making across theErascaportfolio.Participate inbuildingandmaintaininga culture of rigorous data-driven decision making.
• Lead the clinical developmentsubteamfor all studies in lungcancers.
• Design and implementnovel and efficientclinical trialstoassessappropriate endpoints.
• Responsible for leading clinical studysubteams,monitoringoverall study integrity, and review, interpretation,and communication of safety and efficacy data.
• Provide overall strategy for clinical aspects of registrational strategies, interactions, and filings. Contribute to global regulatory filings and health authority interactions, including authoring clinical sections for INDs,NDAsand other related documents.
• Serve asMedicallead on clinical programsand r epresent Clinical Development on program teams.
• Partner with Drug Safety to assess the safety profile of compounds.
• Writeor partner in the authoring ofmedical aspects of core study and regulatory documents including clinical research plans, protocols, investigator brochures, clinical studyreportsand regulatory submissions.
• Contribute to the development and review of scientific publications; author manuscripts and collaborate with cross-functional colleagues and thought leaders to meet publication planobjectives.
• Present at scientific, medical,and regulatory meetings.
• Maintaina high levelof clinical and scientificexpertiseby reviewing literature, attending medicalorscientific meetings,and through personalexchangewiththought leaders, investigators,and internal stakeholdersand partners.
• Participate in due diligence or other business development activities.
• Hire, develop, and mentor a high functioning team of medical directors and clinical scientists.
• Establish, develop,andmaintainrelationships acrossErasca, particularly with partners and stakeholders inResearch andDevelopment.
• Perform all duties in keeping with the Company’s core values,policiesand all applicable regulations.

Required Education and Experience:

• M.D.degreeor equivalent, with subspecialtyfellowshiptraining and board certification or eligibility in Oncology or Oncology/Hematologyrequired.Additionaltraining and clinical practiceexperiencein thoracic oncology preferred.
• 8-10+ years ofoncologyclinical trial anddrug development experience,including extensive experience in the pharmaceutical or biotechnology industry.The ideal candidate will bringa combination of clinical practice, academic clinical trials,and industry experience,withbothlarge and small companyexperiencea plus.
• Experience as the clinical lead on late-stage clinical programs in lung cancer highly preferred.
• Experience leading or beingclosely involvedinthe clinical aspects of aregulatory filing and direct interaction with health authoritiesrequired.
• Exposure to early development and the transition from FIH to registrational trials preferred.
• Extensive knowledge of clinical trialmethodologyand theregulatory and compliance requirements governing clinical trials.
• Demonstrated ability to collaborate successfully with multiple functions in amatrixedteam environment.
• Executive leadership skills to educate and influence stakeholders and to add valueinstrategic business planning and decision-making.
• Effective interpersonal, communication and influencing skills, including excellent writing skills, with the ability to tailor communication style to diverse audiences and situations.
• Demonstrated ability to achievehigh performancegoals and meet deadlines in a fast-paced environment; a collaborative team player with a can-do attitude and the ability toidentifyand implement creative solutions to complex problems.
• Strong learning orientation, curiosity, andcommitment toscience and patients.

The anticipated salary range for this position is $390,000 to $435,000 . The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc etera. In addition to base salary, the h ired applicant will be eligible to receive an annual bonus and an equity grant at hire and annually in the form of the option to purchase stock in the future for a specified price.

Along with our casual, collaborative , and fun work and the chance to make your mark in our mission to erase cancer, Erasca offers a comprehensive and competitive benefits package that includes: Paid Time Off , Holiday , and Sick Leave , Medical, Dental and Vision Plans , Short- and Long-Term Disability , Basic and Voluntary Life/AD&D Coverage , Flexible Spending Account s (FSA , HSA, and Commute ) , Critical Illness and Accident Coverage , Pet Insurance, Employee Assistance Program , 401(k) Plan with Erasca contribution , and the opportunity to participate in an E mployee S tock P urchase P rogram.

Erasca, Inc., is an Equal Opportunity Employer and takes pride in maintaining a diverse and inclusive environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of sex , race , religion, national origin, ancestry, physical or mental disability, protected medical condition, genetic information, marital status, registered domestic partner status, age, sexual orientation, military and veteran status or any other basis protected by federal, state or local law or ordinance or regulation.