Vice President, Portfolio Chemistry

Revolution Medicines, Inc.; California (MO); On-site; USD 294,000 - 367,000; Full time

Benefits offered by this job

Equity

Competitive compensation

Benefits

Job summary

Scorpion Therapeutics in Redwood City, CA seeks a Vice President, Portfolio Chemistry to lead medicinal chemistry and related sciences across oncology programs from hit validation to IND-enabling studies.

You will integrate AI/ML and digital tools into discovery, oversee planning and resources, and collaborate with senior research leadership and CROs to ensure seamless program progression.

The role offers competitive compensation, equity, and benefits.

Qualifications

• PhD in Organic Chemistry required.
• 16+ years in industrial drug discovery with leadership.
• Expertise in medicinal chemistry and structure-based design.
• Experience with computational chemistry and external collaborations.

Responsibilities

• Develop and execute long-term chemistry strategy.
• Lead oncology small-molecule programs from hit validation to IND-enabling studies.
• Integrate AI/ML into discovery workflows.
• Collaborate with senior leadership and external CROs to ensure program progression.

Skills

Medicinal chemistry

Structure-based design

Optimization

Computational chemistry

External collaborations

Leadership

Education

Ph.D. in Organic Chemistry

Job description

Role

Vice President, Portfolio Chemistry, leading Revolution Medicines' medicinal chemistry and related sciences to advance oncology programs from hit validation through development candidate nomination.

Responsibilities

develop and execute long-term chemistry strategy, integrate computational, AI/ML, and digital tools into discovery workflows, oversee organizational planning, resource allocation, and foster collaboration across research functions to ensure seamless program progression.

Requirements

• Ph.D. in Organic Chemistry;
• 16+ years in industrial drug discovery with proven leadership supporting multiple discovery programs;
• deep expertise in medicinal chemistry, structure-based design, and optimization;
• experience with computational chemistry and external collaborations.

Preferred

• oncology drug discovery experience,
• successful IND filings,
• clinical candidate delivery,
• patents/publications,
• experience with modalities like molecular glues or ADCs.

High-value specifics

leadership in oncology small-molecule programs, from hit validation to IND-enabling studies, with experience integrating AI/ML into discovery.

Collaboration

Collaboration with senior research leadership, external CROs, and cross-functional teams is essential.

Work setup

onsite at Redwood City, CA, with salary range $294K-$367K, inclusive of competitive compensation, equity, and benefits.