Vice President, Bioconjugation Process Development

AL Solutions; États-Unis; Sur place; USD 240 000 - 360 000; Plein temps

Avantages offerts par ce poste

Relocation assistance

Résumé du poste

AL Solutions in Philadelphia is seeking a Vice President of Bioconjugation Process Development. This senior role will steer the bioconjugation development strategy, manage a skilled team, and drive scale-up and technology transfer into GMP manufacturing.

The candidate will lead discovery and development activities, oversee downstream purification, analytical characterization and process transfer, and act as a senior technical trusted advisor to clients.

Qualifications

• PhD or BS/MS with extensive bioconjugation experience in biotech/biopharma/CDMO.
• Experience leading bioconjugation development teams and training scientists.
• Strong track record transferring processes into GMP manufacturing.

Responsabilités

• Define and lead strategy for bioconjugation process development.
• Oversee conjugation, purification, characterization and scale-up for GMP readiness.
• Establish critical parameters, QA attributes, control strategies and development plans.
• Own transfer readiness and documentation for GMP manufacturing.
• Provide senior scientific oversight during GMP campaigns and troubleshoot issues.
• Build and mentor scientists and leaders within the Bioconjugation group.
• Represent development strategies to clients and contribute to proposals.

Connaissances

Bioconjugation process development

Leadership

Client presentations

Formation

PhD in Chemistry/Biochemistry/Chemical Engineering/Bioengineering/Bioprocessing or related

MS/BS in Chemistry/Biochemistry/Chemical Engineering/Bioengineering/Bioprocessing or related

Outils

GMP knowledge

Process transfer

Description du poste

Vice President, Bioconjugation Process Development | Philadelphia Relocation Opportunity

George Higginson is partnering with a leading biologics CDMO to appoint a Vice President of Bioconjugation Process Development in Philadelphia, PA.

This is a senior scientific leadership opportunity for someone who has taken ADC, AOC or other complex bioconjugate processes from development through scale-up, technology transfer and GMP manufacturing. You will set the technical direction for the bioconjugation process-development function, build and lead its team, and play a key role in the site’s growth.

This position will lead bioconjugation discovery and development activities, including conjugation process development, downstream purification, analytical characterization, scale-up, and technical transfer into manufacturing.

You will serve as a technical subject-matter expert for internal teams and clients while managing and mentoring scientists within the Bioconjugation Development group.

Responsibilities:

• Define and lead the scientific and technical strategy for bioconjugation process development.
• Oversee conjugation, purification, process characterization and scale-up, ensuring processes are robust and ready for GMP execution.
• Establish critical process parameters, quality attributes, control strategies and risk-based development plans.
• Own the technical readiness of processes transferring into GMP manufacturing, including readiness reviews and transfer documentation.
• Provide senior technical oversight during GMP campaigns and lead the response to complex process or manufacturing challenges.
• Build, lead and develop scientists, technical leaders and people managers while prioritising resources across client programmes.
• Serve as a senior scientific representative to clients, presenting development strategies, risks and technical recommendations.
• Partner with Business Development to scope programmes, develop proposals and support technical discussions with prospective clients.
• Contribute to their site strategy, capability development and investment priorities.

Requirements:

• PhD with 8+ years of relevant industry experience, or a BS/MS with 10+ years of experience in biotherapeutic development or bioconjugation.
• Significant senior-level experience in bioconjugation process development within biotech, biopharma or a CDMO.
• Direct experience with ADCs, AOCs or other complex bioconjugate therapeutics.
• Deep expertise in conjugation chemistry, protein handling, purification, process characterization and scale-up.
• A track record of transferring bioconjugation processes into GMP manufacturing and supporting their execution.
• Strong understanding of CMC development, process controls and phase-appropriate GMP expectations.
• Proven experience leading scientific teams and developing senior technical talent.
• Confidence presenting complex technical strategies to clients and contributing to proposals or statements of work.
• A PhD, MS or BS in Chemistry, Biochemistry, Chemical Engineering, Bioengineering, Bioprocessing or a related discipline.

Preferred Experience:

• Design of Experiments and bioprocess optimization
• Technical transfer of bioconjugation processes into GMP manufacturing
• Large-scale and single-use bioprocess equipment
• Client scoping, proposal development, and bid-defence activities
• CDMO or client-facing development environment

Why This Role?

You will have genuine ownership of the bioconjugation development strategy, influence site-level decisions and help clients turn challenging science into scalable manufacturing processes.

Please Note:

These are full-time, on-site roles based in Philadelphia, PA.

Relocation assistance is available, and we welcome applications from candidates across the U.S. who are open to relocating.