UNIV - Post Doctoral Scholar - Surgery: Cancer Immunology and Hepatocellular Carcinoma

MUSC Health

Charleston (SC)

In loco

USD 52.000 - 65.000

Tempo pieno

3 giorni fa

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Descrizione del lavoro

Medical University of South Carolina (MUSC) seeks a Postdoctoral Research Fellow to join a translational cancer lab focused on hepatocellular carcinoma, tumor immunology, inflammation, and cancer metabolism. The role emphasizes in vivo experiments, flow cytometry, and multi-omics approaches within a collaborative environment at Hollings Cancer Center.

The successful candidate will design and execute experiments, analyze data, and contribute to publications and grant applications.

Competenze

PhD required in biology/biomedical sciences or related.
Hands-on experience with mouse cancer models and tumor immunology.
Proficiency in multiparameter flow cytometry and immune profiling.
Experience with molecular biology techniques (PCR/qPCR, RNA isolation).
Ability to design, troubleshoot, and independently conduct experiments.

Mansioni

Conduct mouse HCC experiments including tumor implantation and interventions.
Perform multiparameter flow cytometry and immune cell analysis of tumors.
Carry out RNA isolation, PCR/qPCR, IHC/IF, and single-cell sequencing sample prep.
Analyze data, generate figures, draft manuscripts, and present results.
Contribute to grant applications and multidisciplinary collaborations.

Conoscenze

Mouse cancer models

Multiparameter flow cytometry

Molecular biology techniques

Independent researcher

Tumor immunology

IHC/IF

Single-cell RNA sequencing data

Grant/writing

In vivo experimental design

Scientific communication

Formazione

PhD in biology/biomedical sciences

Strumenti

Flow cytometer

PCR/qPCR

RNA isolation

IHC/Immunofluorescence

Single-cell sequencing

Descrizione del lavoro

Job Description Summary

The Department of Surgery at the Medical University of South Carolina (MUSC), in collaboration with Hollings Cancer Center, is seeking a highly motivated Postdoctoral Research Fellow to join a translational cancer research laboratory focused on hepatocellular carcinoma (HCC), tumor immunology, inflammation, and cancer metabolism. Our laboratory investigates how chronic inflammation, metabolic dysfunction, and the tumor microenvironment influence cancer progression and responses to immunotherapy. Current research focuses on inflammatory signaling pathways, including iNOS/NOS2 and COX-2/PGE2, and the mechanisms by which exercise and metabolic interventions alter tumor immunity and therapeutic responses. The successful candidate will conduct experimental studies using mouse models of hepatocellular carcinoma, with particular emphasis on tumor immunology, immune cell characterization, and molecular mechanisms of inflammation. We are particularly interested in candidates with strong hands-on experience in mouse experimentation and multiparameter flow cytometry. The ideal candidate will be capable of independently designing and conducting in vivo experiments, performing immunological assays, analyzing experimental data, and contributing to scientific publications and grant applications. The position offers opportunities to participate in a growing translational research program integrating preclinical mouse models, human tumor specimens, single-cell technologies, and collaborative clinical research. We welcome applications from international scientists and international medical graduates interested in dedicating 2-3 years to research, including individuals seeking substantial research experience before applying to residency training programs in the United States.

Entity

Medical University of South Carolina (MUSC - Univ)

Worker Type

Employee

Worker Sub-Type

Regular

Cost Center

CC001074 COM SURG Transplant Surgery CC

Pay Rate Type

Salary

Pay Grade

University-00

Pay Range

0.00 - 0.00 - 0.000

Scheduled Weekly Hours

Job Duties

30% - Animal Models and In Vivo Research - Conduct mouse HCC experiments, including tumor implantation, exercise interventions, therapeutic treatments, animal monitoring, and tissue collection.
25% - Flow Cytometry and Immunological Analysis - Perform multiparameter flow cytometry, immune cell isolation, staining, acquisition, gating, and functional characterization of tumor-infiltrating immune populations.
20% - Molecular Biology and Tissue Analysis - Perform RNA isolation, PCR/qPCR, immunohistochemistry, immunofluorescence, and sample preparation for single-cell RNA sequencing.
15% - Data Analysis and Scientific Publications - Analyze experimental data, prepare scientific figures, interpret results, draft manuscripts, and present research findings
10% - Grant Development and Research Collaboration - Contribute to grant applications, research proposals, experimental planning, and multidisciplinary scientific collaborations.

Preferred Qualifications

Experience with mouse cancer models, including
Demonstrated hands-on experience with mouse models, including animal handling, experimental procedures, subcutaneous or orthotopic tumor models, and tissue harvesting.
Practical experience with multiparameter flow cytometry, incuding sample preparation, antibody staining, acquisition, gating strategies, and data interpretation.
Experience with molecular biology techniques, including PCR, qPCR, RNA isolation, or related assays.
Ability to independently design, conduct, troubleshoot, and analyze laboratory experiments.
Strong organizational, analytical, and problem-solving abilities.
Effective written and verbal scientific communication skills.
Ability to work independently while contributing to a collaborative, multidisciplinary research environment.
Background in tumor immunology, cancer inflammation, T-cell biology, macrophage biology, or myeloid cell function.
Experience with immune checkpoint blockade or other cancer immunotherapy approaches.
Familiarity with exercise physiology, metabolic disease, obesity, or metabolic dysfunction-associated steatotic liver disease (MASLD/MASH).
Experience with immunohistochemistry, immunofluorescence, or other tissue-based imaging techniques.
Experience with single-cell RNA sequencing, transcriptomics, or computational analysis of gene-expression data.
Familiarity with cell culture, immune cell isolation, and ex vivo functional assays.
A record of peer-reviewed scientific publications.
Experience contributing to scientific manuscripts, fellowship applications, or grant proposals.
Interest in committing 2-3 years to full-time research.

Research Environment And Professional Development

The successful candidate will join the Department of Surgery at MUSC and conduct research within the collaborative scientific environment of Hollings Cancer Center, an NCI-designated cancer center. Our research program combines mechanistic cancer immunology with translational investigation to identify therapeutic strategies that improve responses to immunotherapy in hepatocellular carcinoma. The laboratory's research interests include inflammatory signaling, immune cell dysfunction, tumor-host interactions, metabolic regulation of immunity, and the effects of exercise on cancer biology.

The Postdoctoral Fellow Will Have Opportunities To

Develop and lead research projects under the mentorship of the principal investigator.
Gain expertise in preclinical tumor models, multiparameter flow cytometry, molecular immunology, and advanced single-cell technologies.
Collaborate with scientists specializing in cancer biology, immunology, metabolism, and translational medicine.
Present original research at national and international scientific conferences.
Serve as a leading author on peer-reviewed publications.
Participate in manuscript preparation and competitive grant applications.
Develop the scientific and professional skills necessary for an academic or research career.

We seek a motivated scientist who is intellectually curious, experimentally rigorous, and interested in contributing to a developing research program with opportunities for scientific growth and increasing independence.

International Applicants And Residency Career Pathways

We particularly welcome motivated international medical graduates who wish to dedicate 2-3 years to full-time research before pursuing residency training in the United States. This position offers an opportunity to gain substantive research experience in an academic medical center, develop expertise in experimental cancer biology, contribute to peer-reviewed scientific publications, and establish a strong foundation for future academic or clinical training. Candidates interested in U.S. residency training will benefit from mentorship in scientific writing, research presentations, academic career development, and navigating the U.S. academic research environment. Applicants are expected to demonstrate a genuine commitment to research and scientific productivity throughout their appointment. International applicants may be considered subject to applicable employment authorization requirements and MUSC policies regarding visa sponsorship.

If you like working with energetic enthusiastic individuals, you will enjoy your career with us!

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.

Medical University of South Carolina participates in the federal E-Verify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program, please click here: http://www.uscis.gov/e-verify/employees

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