Translational Pharmacology, Omics, & AI - Assistant/Associate Professor - Tenure Track

Cincinnati Children's Office of Academic Affairs and Career Development; Cincinnati (OH); On-site; USD 140,000 - 210,000; Full time

Job summary

Cincinnati Children’s Hospital Medical Center invites applications for a Tenure-Track faculty position at the Assistant or Associate Professor level in the Division of Translational and Clinical Pharmacology.

The successful candidate will build an independent, externally funded program using big biological and multi-omics datasets to unravel how drugs and exposures affect pediatric health and disease, with emphasis on integrating multi-omics data for mechanism discovery and precision

Qualifications

• PhD, MD/PhD, PharmD/PhD, or equivalent in computational biology, bioinformatics, biomedical data science, pharmacometrics, systems pharmacology, toxicology, pharmacology, engineering, computer science, or a related discipline.
• Demonstrated expertise in computational and quantitative approaches applied to biomedical research.
• Experience analyzing and integrating large-scale biological, environmental, clinical, proteomic, metabolomic, exposomic, genomic, or other multi-omics datasets.
• Strong publication record and demonstrated potential for independent extramural funding.
• Commitment to collaborative and team-based translational science.

Responsibilities

• Develop an independent, externally funded research program leveraging big data to understand pediatric disease and therapeutic response.
• Create computational frameworks that integrate proteomic, metabolomic, exposomic, genomic, and clinical data for biomarker discovery and drug repurposing.
• Lead AI/ML and quantitative modeling efforts to accelerate pediatric and rare disease therapeutics.
• Collaborate across translational teams to translate computational findings into clinical impact.

Skills

Computational biology

Bioinformatics

Biomedical data science

Pharmacometrics

Systems pharmacology

Computer science

Education

PhD, MD/PhD, PharmD/PhD, or equivalent

Job description

Primary Location

Location S

Department

Transl and Clin Pharmacology

Shift

Day (United States of America)

Schedule

Full time

Weekly Hours

40

FTE

1

Employee Status

Regular

Assistant or Associate Professor (Tenure-Track)

The Division of Translational and Clinical Pharmacology (TCP) at Cincinnati Children's Hospital Medical Center (CCHMC) invites applications for a Tenure-Track faculty position at the Assistant or Associate Professor level. We seek an innovative and collaborative computational scientist with expertise in quantitative pharmacology, systems pharmacology, artificial intelligence/machine learning (AI/ML) or bioinformatics. Complementary expertise in exposomics, proteomics, metabolomics, multi-omics integration, mechanistic modeling, or related quantitative disciplines is highly desirable.

The successful candidate will develop an independent, externally funded research program leveraging large-scale biological, clinical, environmental, and/or multi-omics datasets to understand how drugs, environmental exposures, nutrition, microbiome-derived factors, and genetic variation influence pediatric disease, therapeutic response, and lifelong health outcomes. Particular emphasis will be placed on developing computational frameworks that integrate proteomic, metabolomic, exposomic, genomic, and clinical data to identify disease mechanisms, discover biomarkers, predict therapeutic response, enable drug repurposing, and accelerate treatment development for pediatric and rare diseases.

Research programs that integrate exposomics, proteomics, metabolomics, human-relevant New Approach Methodologies (NAMs), patient-derived organoids, microphysiological systems, and real-world clinical data with AI/ML-enabled predictive frameworks are particularly encouraged. Applications focused on rare diseases, precision therapeutics, drug repurposing, biomarker discovery, disease progression modeling, digital twins, or model-informed precision dosing are of special interest.

Required Qualifications

• PhD, MD/PhD, PharmD/PhD, or equivalent in computational biology, bioinformatics, biomedical data science, pharmacometrics, systems pharmacology, toxicology, pharmacology, engineering, computer science, or a related discipline.
• Demonstrated expertise in computational and quantitative approaches applied to biomedical research.
• Experience analyzing and integrating large-scale biological, environmental, clinical, proteomic, metabolomic, exposomic, genomic, or other multi-omics datasets.
• Strong publication record and demonstrated potential for independent extramural funding.
• Commitment to collaborative and team-based translational science.

Preferred Qualifications

• Expertise in AI/ML, deep learning, generative AI, foundation models, causal inference, graph learning, or advanced statistical methods.
• Experience integrating exposomics, proteomics, metabolomics, genomics, imaging, wearable sensor, or clinical datasets.
• Expertise in PBPK, PopPK, PK/PD, QSP, systems biology, or mechanistic modeling.
• Interest in rare diseases, pediatric therapeutics, precision medicine, environmental health, or drug repurposing.
• Experience developing computational tools or predictive models for biomarker identification, disease progression, or therapeutic optimization.
• Experience working with cloud computing, high-performance computing, or large biomedical datasets.

TCP Description

TCP is internationally recognized for leadership in pediatric clinical and translational pharmacology, pharmacometrics, quantitative proteomics, metabolomics, exposomics, physiologically based pharmacokinetic (PBPK) modeling, quantitative systems pharmacology (QSP), environmental health sciences, model-informed precision dosing (MIPD), and model-informed drug development (MIDD). The division is actively expanding its computational capabilities in AI/ML, biomedical data science, systems biology, multi-omics analytics, and predictive modeling to enable the next generation of pediatric therapeutics and precision medicine.

About Us

At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a holistic team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.

Cincinnati Children's Is

• Recognized by U.S. News & World Report as atop 10 best Children's Hospitals in the nation for more than 15 years
• Consistently among the top 3 Children's Hospitals for National Institutes of Health (NIH)Funding
• Recognized as one of America’s Best Large Employers (2025), America’s Best Employers for New Grads (2025)
• One of the nation'sAmerica’s Most Innovative Companiesas noted by Fortune
• Consistently certified as great place to work
• A Leading Disability Employeras noted by theNational Organization on Disability
• Magnet® designated for the fourth consecutive time by theAmerican Nurses Credentialing Center (ANCC)

We Embrace Innovation—Together. We believe in empowering our teams with the tools that help us work smarter and care better. That’s why we support the responsible use of artificial intelligence. By encouraging innovation, we’re creating space for new ideas, better outcomes, and a stronger future—for all of us.

Comprehensive Job Description Provided Upon Request.

Cincinnati Children’s is proud to be an Equal Opportunity Employer committed to creating an environment of dignity and respect for all our employees, patients, and families. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, genetic information, national origin, sexual orientation, gender identity, disability or protected veteran status. EEO/Veteran/Disability