Toxicology Lead — AI-Driven Drug Discovery

Isomorphic Labs; Cambridge (MA); Hybrid; USD 220,000 - 320,000; Full time

Job summary

Isomorphic Labs in Cambridge, MA is seeking a Research Leader (Toxicology) to define safety strategies for small molecules and biologics, guiding AI-first toxicology development and regulatory readiness.

You will lead a cross-functional team, mentor junior staff, and collaborate with ML researchers to reduce animal testing while enabling IND/CTA successes in a fast-moving, collaborative environment.

Qualifications

• Excellent communication (written and verbal).
• Demonstrated experience in senior toxicology roles across therapy areas.
• Experience filing INDs/CTAs for small molecules and biologics.
• Deep understanding of global regulatory guidelines for safety assessment.
• Strong collaboration with discovery and clinical teams.

Responsibilities

• Design safety assessment strategies with AI-first approach for drug discovery.
• Develop mechanistic toxicology experiments to support project progression.
• Define regulatory safety packages for regulatory acceptance.
• Partner with ML colleagues to build predictive toxicology models.
• Mentor junior team members and foster inclusive culture.

Skills

Leadership

Cross-functional collaboration

Excellent communication

Problem solving

Growth mindset

Adaptability

Influencing skills

Education

Ph.D. in Toxicology or related field

Board Certification

Tools

Python

KNIME

Job description

Isomorphic Labs in Cambridge, MA is seeking a Research Leader (Toxicology) to define safety strategies for small molecules and biologics, guiding AI-first toxicology development and regulatory readiness.

You will lead a cross-functional team, mentor junior staff, and collaborate with ML researchers to reduce animal testing while enabling IND/CTA successes in a fast-moving, collaborative environment.