T Cell Therapy Scientist — Flow Cytometry & Engineering

Genentech; San Francisco (CA); On-site; USD 103,000 - 192,000; Full time

Benefits offered by this job

Relocation benefits

Job summary

Genentech is seeking a scientist in the Cell Therapy department (gRED) to advance novel T cell-based therapies for patients with intractable diseases. You will culture primary T cells, engineer cells, and develop robust flow cytometry assays to characterize identity and function.

The role requires a PhD/MD/DVM or equivalent with at least 3 years of relevant experience, strong collaborative skills, and a track record of solving complex biological problems.

Qualifications

• PhD, MD, DVM or equivalent with at least 3 years of relevant experience.
• Hands-on experience with primary T cell isolation, activation, culture, expansion and phenotypic characterization.
• Deep knowledge of T cell biology across development, differentiation, effector function, exhaustion, memory and survival.
• Advanced multiparameter flow cytometry, panel design, controls, assay optimization, data analysis and interpretation.
• Experience engineering primary immune cells using viral and non-viral gene delivery methods.
• Experience developing and executing cell-based functional assays relevant to T cell biology or cell therapy.
• Strong experimental design, troubleshooting, and interpretation of multidimensional datasets.
• Record of scientific or process contributions evidenced by publications, patents, or therapeutic programs.
• Strong organizational and communication skills; ability to document and present results to multidisciplinary teams.

Responsibilities

• Culture and engineer primary T cells and other relevant cell types.
• Develop and apply multiparameter flow cytometry assays to characterize T cell identity, differentiation state, activation, function, and fitness.
• Evaluate engineered T cells using phenotypic and functional assays, including proliferation, cytokine production, cytotoxicity and persistence-related measurements.
• Analyze complex datasets, draw conclusions and guide subsequent experimental strategy.
• Collaborate with research, translational, computational, process development and other partner groups across and outside gRED.
• Maintain comprehensive and accurate experimental records using electronic laboratory systems.
• Communicate findings clearly through written reports, data packages and presentations to project teams and stakeholders.
• Contribute to scientific and strategic planning for the Cell Therapy department and Genentech’s broader cell therapy pipeline.

Skills

T cell biology

primary T cell culture

multiparameter flow cytometry

immune cell engineering

data analysis

experimental design

scientific communication

Education

PhD, MD, DVM or equivalent

Tools

Flow cytometry panels

Job description

Genentech is seeking a scientist in the Cell Therapy department (gRED) to advance novel T cell-based therapies for patients with intractable diseases. You will culture primary T cells, engineer cells, and develop robust flow cytometry assays to characterize identity and function.

The role requires a PhD/MD/DVM or equivalent with at least 3 years of relevant experience, strong collaborative skills, and a track record of solving complex biological problems.