Synthetic Chemist – Peptide Therapeutics (Indianapolis, IN)

Eli Lilly and Company; Indianapolis (IN); On-site; USD 63,000 - 163,000; Full time

Job summary

An established industry player is seeking a passionate Associate Synthetic Chemist to join their Peptide Therapeutics group. This role offers an exciting opportunity to contribute to preclinical drug discovery efforts, working alongside a multidisciplinary team of researchers. The ideal candidate will possess a solid foundation in synthetic peptide chemistry and organic chemistry, with a willingness to learn and adapt. You will engage in cutting-edge research, synthesize target molecules, and collaborate across various scientific disciplines to develop innovative biotherapeutics. If you're eager to make a significant impact in healthcare, this position is perfect for you.

Qualifications

• 2+ years of industry experience in synthetic chemistry.
• Understanding of peptide synthesis and organic chemistry.

Responsibilities

• Utilize synthesis techniques for compound generation and purification.
• Collaborate with chemists and scientists to drive projects forward.

Skills

Synthetic Peptide Chemistry

Organic Chemistry

Analytical Skills

Communication Skills

Problem-Solving

Education

B.S. in Chemistry

M.S. in Chemistry

Tools

HPLC

Mass Spectrometry

Job description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $63,000 - $162,800.

Organization Overview:

The Peptide Therapeutics group at Lilly is seeking to recruit a full-time Associate Synthetic Chemist. The successful applicant will be an enthusiastic and highly motivated team player who will make significant contributions to preclinical drug discovery and development efforts. This is an exciting opportunity to join a multidisciplinary team of researchers working to develop the next generation of peptide-related biotherapeutics across a range of therapeutic areas. Creative, enthusiastic, and highly motivated synthetic chemists with limited peptide chemistry experience and deeper expertise in the areas of small molecules, oligonucleotides, or protein conjugation are welcome to apply.

Responsibilities:

• Utilize state-of-the-art synthesis techniques to drive compound generation.
• Synthesize target molecules, perform purification and QC analysis, propose alternative synthetic strategies, and overcome synthetic challenges.
• Analyze and interpret structure-activity relationships to make design recommendations to drive projects forward.
• Collaborate with fellow chemists and scientists from other disciplines and drug modalities in a team environment that is focused on achieving success.
• Search relevant chemical and scientific literature with limited supervision.
• Accurately document experimental procedures and communicate results via verbal presentations and written reports.

Basic Requirements:

• B.S. in Chemistry or a related field with at least 2 years of industry experience OR M.S. in Chemistry or a related field with experience.

Additional Skills/Preferences:

• A comprehensive understanding of synthetic peptide chemistry and/or organic chemistry is critical.
• Experience with peptide synthesis instrumentation, purification, and analysis by HPLC and mass spectrometry is desirable but not necessary. Skilled synthetic organic chemists with a desire to transition to the area of peptide therapeutics are encouraged to apply.
• Experience with synthesis, characterization, and optimization of macrocyclic peptides is preferable.
• Experience in the bioconjugation of fluorescent labels, carbohydrates, oligonucleotides, small molecules and/or proteins to synthetic peptides or other modalities is valuable.
• Experience in structure-based drug design using computational methods is beneficial.
• The successful candidate will have superb communication and organizational and interpersonal skills and will excel working as part of diverse cross-functional teams.
• Essential traits include a desire to present their work and understand its impact on drug discovery efforts, and an eagerness to take on diverse scientific and technical challenges as they arise.