Supervisor, Oncology RUO

Natera; San Carlos (CA); On-site; USD 82,000 - 103,000; Full time

Job summary

Natera's Oncology RUO team seeks a Supervisor for the Signatera Plasma Team. You will oversee staff executing cfDNA extraction, library preparation, and NGS workflows to advance MRD assays. You’ll also manage SOPs, ensure PHI/privacy, and drive process improvements in a fast-paced clinical pipeline.

Ideal candidates have a BS/BA in a biological science and 3–4 years’ lab leadership experience, with familiarity in LIMS and laboratory automation platforms.

Qualifications

• BS/BA in biological sciences or equivalent.
• Experience with cfDNA or MRD assays is a plus.

Responsibilities

• Oversee daily scheduling of lab staff performing DNA extractions, library prep, QC, and NGS workflows.
• Provide data-backed performance evaluations and guide career development.
• Direct hands-on sample processing to maintain throughput.
• Serve as primary technical contact to guide data interpretation and troubleshooting.
• Draft and review SOPs and work instructions.

Skills

Nucleic acid techniques

NGS workflows

LIMS proficiency

Office 365 & Google Workspace

Lab automation platforms

Data analysis

Team management

Education

BS/BA in biological science or equivalent

Tools

LIMS systems

NGS platforms

Library preparation instruments

Job description

Join Natera's Oncology Research Use Only (RUO) team as a Supervisor for the Signatera Plasma Team. You will direct laboratory staff executing cell-free DNA (cfDNA) extraction, library preparation, and Next-Generation Sequencing (NGS) workflows to advance our personalized Minimal Residual Disease (MRD) assays. Every sample represents a real person, and you will ensure that all lab processes operate with the pace and precision required to support our clinical pipeline.

PRIMARY RESPONSIBILITIES

• Oversee the daily scheduling of employees executing DNA extractions, library preparation, Nucleic Acid Quality Control (QC), and NGS workflows
• Conduct regular 1:1 meetings to deliver unvarnished, data-backed performance evaluations and guide career development
• Take ownership of daily lab operations by directly executing sample processing alongside the team to maintain throughput
• Serve as the primary technical point of contact, using data to guide team members on data interpretation, next steps, and troubleshooting
• Execute process development and method/instrument testing to increase operational precision and scale
• Use data to identify lab process deviations, root-cause the underlying issues, and document findings via nonconformance reports to drive corrective action
• Draft, generate, and rigorously review Standard Operating Procedures (SOPs) and work instructions
• Maintain precise records of lab work using Google Sheets, Microsoft Excel, and internal Laboratory Information Management Systems (LIMS)
• Ensure accurate, ethical, and appropriate management of samples in strict compliance with all applicable federal regulations
• Think team by partnering directly with Oncology RUO peer groups to eliminate bottlenecks and optimize sample processing without needing translation layers
• Present data-backed summaries on team activities, project milestones, and timeline adherence
• Adapt to evolving science and operational needs, taking ownership of tasks that move the work forward without waiting for a finished playbook
• Handle protected health information (PHI) in paper and electronic formats as required to perform duties
• Complete required HIPAA/PHI privacy and security training within the first 30 days of hire and maintain current status on all training

QUALIFICATIONS

• BS/BA in a biological science or equivalent
• 3 to 4 years of related laboratory experience
• Prior team management experience is highly preferred
• Must pass a post-offer criminal background check

KNOWLEDGE, SKILLS, AND ABILITIES

• Direct hands-on experience with nucleic acid techniques, including isolation, purification, quantification, amplification, and hybridization capture
• Extensive familiarity with rigorous pipetting practices using single- and multi-channel micropipettes and serological pipettes
• Hands-on experience operating Laboratory Automation platforms (e.g., Hamilton, Tecan, Biomek, QIAsymphony)
• Hands-on experience with library preparation and NGS platforms
• Proficiency with LIMS and database software
• Proficiency with Microsoft Office and Google Workspace applications
• Experience leading a lab team, spanning scheduling, training, workload prioritization, and building an execution-focused culture, is a plus
• Ability to think analytically, testing assumptions with data to troubleshoot and solve complex problems
• Clear, direct oral and written communication skills to present data and identify operational improvements
• Demonstrated interpersonal skills to build effective working relationships within the functional area
• Manage competing priorities while operating with pace and precision in an evolving scientific environment

PHYSICAL DEMANDS AND WORK ENVIRONMENT

• Duties are typically performed in an office and laboratory setting on a daily basis
• Requires the ability to perform repetitive motions during pipetting and sample processing
• Requires the ability to use a computer keyboard and read printed material
• Requires onsite work in San Carlos, CA, and flexibility to work shifted schedules (e.g., 7am-4pm, 11am-8pm, 7pm-3am) with a 30-minute break
• Weekend shifts may be scheduled based on operational demand
• May require lifting or moving items weighing up to 25 lbs

Compensation & Total Rewards

This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and skills considerations.

This positionis also eligible for additional compensation and benefits throughNatera's robust Total Rewards program, including:

401(k) with company match

Generous paid time off and company holidays

Additional wellness and work-life benefits

Compensation Range

$82,300 - $102,850 USD

OUR OPPORTUNITY

Natera is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women's health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents.

Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the