Product Manager, Lab Execution Oncology (Signatera) New US Remote

Natera, Inc.; San Carlos (CA); Hybrid; USD 128,000 - 152,000; Full time

Job summary

Natera, Inc. is seeking a Product Manager for Lab Execution Oncology (Signatera) to own genomics workflows from sample intake to sequencing.

You’ll collaborate with Lab Ops, R&D, and Automation to translate needs into clear software requirements and deliver reliable lab processes on the floor. Expect to ship features that improve throughput and reduce errors, with regulatory awareness and data-driven decision making.

Qualifications

• Experience in product management, ideally in regulated domains such as healthcare or labs.
• Ability to write clear requirements and user stories.
• UX design thinking with a focus on user-centered workflows.
• Interest in genomics workflows and ability to learn complex processes quickly.
• Analytical mindset with comfort using data to inform decisions.
• Familiarity with Agile frameworks and tools like Jira/Confluence.

Responsibilities

• Own features and enhancements for an NGS lab workflow, aligned with roadmap and priorities.
• Write clear user stories and acceptance criteria for engineering execution.
• Create flow diagrams, wireframes, and prototypes to clarify requirements.
• Bring UX thinking to create intuitive workflows reducing errors and training time.
• Groom and prioritize backlog with engineering, balancing features, bugs, and quality improvements.
• Identify and close operational gaps on the lab floor (tracking, inventory, disposition).
• Track success metrics (throughput, turnaround, adoption) and iterate based on feedback.

Skills

Product management

User stories

UX design thinking

Genomics workflows

Agile/Scrum

Jira/Confluence

Data analytics

Tools

Jira

Confluence

SQL

Job description

Product Manager, Lab Execution Oncology (Signatera)

US Remote

About the Role

This is your chance to help build the software that runs Natera's Signatera Plasma lab, a high-throughput lab that processes helps patients achieve and stay in cancer remission . You'll own features and genomics workflows across the lab, from sample intake to sequencing. Every feature you ship makes the lab faster and more reliable, and helps patients and families get answers about their genetic health. Your customers are on the lab floor every day, so you'll see the impact of your work right away.

You'll work closely with an engineering team, Lab Operations, R&D, and Automation to turn lab needs into clear requirements and working software. You'll learn the lab inside and out, ask lots of questions, and sweat the details that make Signatera workflows hard, like rework scenarios, process improvements, and task prioritizatioon. You'll bring curiosity, a bias for action, and a willingness to put AI to work so you can move faster and ship smarter.

Key Responsibilities

Product Ownership

• Own features and enhancements for an NGS lab workflow, aligned with the team's roadmap and priorities.
• Write clear user stories and acceptance criteria that engineering can execute on.
• Create flow diagrams, wireframes, and simple prototypes to clarify requirements with lab and technical teams.
• Bring UX design thinking to everything you build, partnering with design to create intuitive workflows that reduce errors and training time on the lab floor.
• Groom and prioritize the backlog with your engineering team, balancing new features, bug fixes, and quality-of-life improvements.
• Find and close operational gaps on the lab floor, such as sample tracking, primer and control inventory, sample disposition, and instrument availability.
• Build robust quality documentation and release notes to enable lab verification and validation.

Delivery & Launch

• Support new product, panel launches and process improvements, through requirements, UAT, lab process verification and validation, go-live, and hypercare.
• Work with Quality and Regulatory to make sure your features meet the requirements of a regulated clinical lab.
• Track success metrics such as throughput, turnaround time, failure and rework rates, manual touchpoints, workcell utilization, and adoption for the features you ship.
• Gather user feedback after launch and turn it into improvements.

Customer & Cross-Functional Collaboration

• Partner with Lab Operations, R&D, Automation, and Bioinformatics stakeholders to understand their needs and pain points.
• Host in-depth user trainings, feedback sessions, and demos to enable a seamless user experience and feature rollouts.
• Work with Automation to integrate software with automated workcells and instruments, including liquid handlers, sample storage, and sequencers.
• Spend real time on the lab floor to understand how people actually work, and build deep empathy for lab operators.
• Keep stakeholders informed on progress, trade-offs, and risks.
• Work with senior product managers and product leadership to grow your skills and contribute to the broader WH/OH strategy.

Qualifications

Required Skills & Experience

• Experience in product management, business analysis, or a related role on software products, ideally in labs, healthcare, or another regulated domain.
• Solid skills in writing requirements and user stories.
• UX design thinking, with an eye for intuitive, user-centered workflows.
• Interest in genomics workflows and the ability to learn complex scientific processes quickly.
• Analytical mindset, comfortable using data and dashboards to inform decisions.
• Familiarity with Agile (Scrum/Kanban) and tools like Jira and Confluence.
• Strong written and verbal communication skills, and the organization to juggle multiple priorities.

Nice to Have

• Based in the Bay Area (San Carlos, CA) or willingness to travel (approx. 25 to 35%).
• Experience working in or with a clinical or molecular lab.
• Familiarity with LIMS/LES or other lab software.
• Exposure to germline, carrier screening, or hereditary testing workflows.
• Experience with lab automation, integrated workcells, or instrument integration.
• Experience with SQL.
• Experience using AI tools to work more efficiently.

Compensation & Total Rewards

This range reflects a good-faith estimate of the base pay we reasonablyexpect to offer at the time of hire.Final compensation will vary based on experience, qualifications, and internal equity considerations.

This positionis also eligible for additional compensation and benefits throughNatera’s robust Total Rewards program, including:

Annual performance incentive bonus

Long-term equity awards

401(k) with company match

Generous paid time off and company holidays

Additional wellness and work-life benefits

Compensation Range

$127,500 - $151,500 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

If you are based in California, we encourage you to read this important information for California residents.